Dalhoff K, Dennin R H, Schulz E, Sack K, Hoyer J
Dtsch Med Wochenschr. 1985 Aug 23;110(34):1279-83. doi: 10.1055/s-2008-1068995.
Incidence and course of herpes simplex infections was determined prospectively in 22 patients who had a kidney transplant and were treated with cyclosporin. In addition to clinical findings, serial studies were undertaken of throat washings for herpes simplex virus in cell culture, as well as of patient sera for herpes-specific IgG and IgM antibodies. There were 13 clinically manifest infections, 12 of them localized, while one had dissemination with necrotizing retinitis. Virus demonstration was successful in all cases in which virostatic drugs had not yet been used. Asymptomatic virus excretion was noted in three cases. Significant IgG titre rise occurred in six of the 13 cases, but a positive IgM titre in only two. Acyclovir proved to be an effective virostatic drug with few side effects. The outcome in the localized infections was favourable, but in the disseminated one residual defects remained.
对22例接受肾移植并使用环孢素治疗的患者进行了单纯疱疹感染发病率和病程的前瞻性研究。除临床检查外，还对咽洗液进行了细胞培养检测单纯疱疹病毒，并检测了患者血清中的疱疹特异性IgG和IgM抗体。共有13例临床表现为感染，其中12例为局限性感染，1例播散并伴有坏死性视网膜炎。在所有尚未使用抗病毒药物的病例中，病毒检测均成功。3例出现无症状病毒排泄。13例中有6例IgG滴度显著升高，但仅2例IgM滴度呈阳性。阿昔洛韦被证明是一种有效的抗病毒药物，副作用较少。局限性感染的预后良好，但播散性感染仍有残留缺陷。
