Schumacher K A, Weidenmaier W E, Rüppel D A, Classen H G
Eur J Radiol. 1985 Aug;5(3):167-74.
Investigations into specific hepatosplenography performed with the aid of radiodense lipomicrons of different size ranges and various surface layers are presented. It is concluded that certain synthetic neutral and/or negatively charged amphiphilic substances may enhance hepatic and splenic uptake of small lipomicrons. Kinetics concerning clearance of lipid globules from the blood and hepatic concentration as well as elimination rates are studied. Furthermore, circulatory reactions following the intravenous administration of lipid emulsions and interactions between lipid globules and plasma proteins or synthetic polymeric substances are discussed.
本文介绍了借助不同尺寸范围和各种表面层的放射性致密脂质微球进行的特定肝脾造影研究。得出的结论是，某些合成中性和/或带负电荷的两亲性物质可能会增强小脂质微球在肝脏和脾脏中的摄取。研究了脂质球从血液中的清除动力学、肝脏浓度以及消除率。此外，还讨论了静脉注射脂质乳剂后的循环反应以及脂质球与血浆蛋白或合成聚合物之间的相互作用。
