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核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

2016 年杰弗里·M·霍格奖演讲。

2016 Jeffrey M. Hoeg Award Lecture.

机构信息

From the Department of Surgery and Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (E.R.).

Department of Medical Biochemistry, Experimental Vascular Biology Laboratory, Academic Medical Center, Amsterdam, The Netherlands (E.L.).

出版信息

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1678-1688. doi: 10.1161/ATVBAHA.118.307742.

DOI:10.1161/ATVBAHA.118.307742
PMID:29930003
Abstract

Innate and adaptive immune effector mechanisms, in conjunction with hyperlipidemia, are important drivers of atherosclerosis. The interaction between the different immune cells and the secretion of cytokines and chemokines determine the progression of atherosclerosis. The activation or dampening of the immune response is tightly controlled by immune checkpoints. Costimulatory and coinhibitory immune checkpoints represent potential targets for immune modulatory therapies for atherosclerosis. This review will discuss the current knowledge on immune checkpoints in atherosclerosis and the clinical potential of immune checkpoint targeted therapy for atherosclerosis.

摘要

先天和适应性免疫效应机制，以及高血脂，是动脉粥样硬化的重要驱动因素。不同免疫细胞的相互作用以及细胞因子和趋化因子的分泌决定了动脉粥样硬化的进展。免疫反应的激活或抑制受到免疫检查点的严密控制。共刺激和共抑制免疫检查点是动脉粥样硬化免疫调节治疗的潜在靶点。本文将讨论动脉粥样硬化中免疫检查点的最新知识以及免疫检查点靶向治疗动脉粥样硬化的临床潜力。

相似文献

[1]
2016 Jeffrey M. Hoeg Award Lecture.

Arterioscler Thromb Vasc Biol. 2018-8

[2]
Exploring immune checkpoints as potential therapeutic targets in atherosclerosis.

Cardiovasc Res. 2018-3-1

[3]
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[4]
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[5]
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Atherosclerosis. 2018-7-6

[6]
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Arch Cardiovasc Dis. 2017-12

[7]
ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.

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[8]
The Innate and Adaptive Immune System as Targets for Biologic Therapies in Inflammatory Bowel Disease.

Int J Mol Sci. 2017-9-21

[9]
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Prog Lipid Res. 2011-5-13

[10]
Atherosclerosis and autoimmunity: a growing relationship.

Int J Rheum Dis. 2018-5

引用本文的文献

[1]
Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4Foxp3 Regulatory T Cell Immunosuppression.

Int J Drug Discov Pharm. 2024-12

[2]
Costimulatory and Coinhibitory Immune Checkpoints in Atherosclerosis: Therapeutic Targets in Atherosclerosis?

JACC Basic Transl Sci. 2024-3-13

[3]
The emerging role of Th1 cells in atherosclerosis and its implications for therapy.

Front Immunol. 2022

[4]
B Cells in Atherosclerosis: Mechanisms and Potential Clinical Applications.

JACC Basic Transl Sci. 2021-6-28

[5]
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.

Nat Commun. 2021-6-18

[6]
Biological drug and drug delivery-mediated immunotherapy.

Acta Pharm Sin B. 2021-4

[7]
Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.

Eur Heart J. 2020-8-14

[8]
Updates on Approaches for Studying Atherosclerosis.

Arterioscler Thromb Vasc Biol. 2019-4

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