Chatelain R E, Dardik B N, Robson R D
Eur J Pharmacol. 1985 Jun 7;112(2):271-5. doi: 10.1016/0014-2999(85)90509-6.
Vascular cyclic AMP alterations were studied during the initiation of vascular hypertrophy and hyperplasia in spontaneously hypertensive rats (SHR). The onset of hypertension at 6 weeks of age coexisted with a three-fold elevation in the aortic content and concentration of cyclic AMP, whereas aortic DNA and protein contents were identical to those of WKY controls. A similar cyclic AMP elevation was present in 12-week-old SHR when vascular hypertrophy and hyperplasia were already established. These experiments suggest the participation of cyclic AMP in the process of hypertensive vascular growth.
在自发性高血压大鼠（SHR）血管肥大和增生起始阶段，研究了血管环磷酸腺苷（cAMP）的变化。6周龄时高血压的出现与主动脉中cAMP含量和浓度升高三倍同时发生，而主动脉DNA和蛋白质含量与WKY对照相同。当12周龄的SHR已经出现血管肥大和增生时，也存在类似的cAMP升高。这些实验表明cAMP参与了高血压血管生长过程。
