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Differences in mechanisms of modulation between rat liver cholesterol 7 alpha-hydroxylase and HMG-CoA reductase.

作者信息

Lidström-Olsson B

出版信息

FEBS Lett. 1985 Sep 9;189(1):124-8. doi: 10.1016/0014-5793(85)80855-3.

DOI:10.1016/0014-5793(85)80855-3
PMID:2993028
Abstract

The effects of microsomal HMG-CoA reductase kinase, cytosolic phosphoprotein phosphatase and cytosolic, thiol-dependent cholesterol 7 alpha-hydroxylase stimulatory protein on purified cholesterol 7 alpha-hydroxylase and HMG-CoA reductase from rat liver were compared. Neither HMG-CoA reductase kinase nor phosphoprotein phosphatase had any significant effect on cholesterol 7 alpha-hydroxylase activity. They inhibited and stimulated, respectively, the activity of HMG-CoA reductase. The purified cytosolic protein which stimulated cholesterol 7 alpha-hydroxylase threefold in the presence of glutathione had no effect on HMG-CoA reductase. The results show that there are separate intracellular systems for modulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase.

摘要

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