Takahashi Takeshi, Harada Masahiro, Kikuno Takaaki, Ujihara Makoto, Sadamitsu Daikai, Manabe Yasuhiro, Yasaka Masahiro, Takayama Hayato, Kobori Shozo, Araki Eiichi
Emergency and Critical Care Center of Kumamoto Medical Center National Hospital Organization Kumamoto Japan.
Emergency and Critical Care Center of Tokyo Medical Center National Hospital Organization Tokyo Japan.
Acute Med Surg. 2013 Oct 18;1(1):17-22. doi: 10.1002/ams2.1. eCollection 2014 Jan.
The fact that Metabolic Syndrome (MetS) increases the risk of atherosclerosis has been epidemiologically studied and proven; however, a prospective study on the prevalence of MetS in stroke patients has never been conducted because of the difficulty in diagnosis under critical illness in the acute phase. Therefore, we conducted a prospective multicenter study to investigate the prevalence of MetS in stroke patients with modified diagnostic criteria for MetS.
Stroke patients admitted in the seven participating Emergency and Critical Care Centers within the two years from April 2007 were registered in this study as a prospective multicenter study. Inclusion criteria were 50 to 89 year-old stroke patients who presented within three days from the onset of symptoms. A total of 992 subjects were classified according to the stroke type and the prevalence of MetS and the associated risk factors were investigated. The participants in a medical checkup without any history of a stroke were enrolled as the control group, and compared between the two groups.
The prevalence of MetS as well as hyperglycemia and dyslipidemia in the infarction group was significantly higher than that in the non-stroke group. While the hemorrhage group showed no significant difference in the prevalence of MetS, only hypertension was significantly high. According to a subtype analysis, there is a significant correlation between waist circumference increment of the stroke patients and the prevalence of the risk factors of hypertension, hyperglycemia and dyslipidemia.
Different risk factors are significantly related to the type of stroke.
代谢综合征（MetS）会增加动脉粥样硬化风险这一事实已得到流行病学研究及证实；然而，由于急性期危重症患者诊断困难，尚未开展关于中风患者中MetS患病率的前瞻性研究。因此，我们开展了一项前瞻性多中心研究，以调查采用改良MetS诊断标准的中风患者中MetS的患病率。
本前瞻性多中心研究纳入了2007年4月起两年内，在7家参与研究的急诊与重症监护中心收治的中风患者。纳入标准为年龄在50至89岁、症状发作后3天内就诊的中风患者。共992名受试者根据中风类型进行分类，调查MetS患病率及相关危险因素。将无中风病史的体检参与者纳入对照组，并对两组进行比较。
梗死组中MetS以及高血糖和血脂异常的患病率显著高于非中风组。出血组中MetS患病率无显著差异，仅高血压患病率显著较高。根据亚组分析，中风患者腰围增加与高血压、高血糖和血脂异常危险因素的患病率之间存在显著相关性。
不同危险因素与中风类型显著相关。
