PACAP 对干眼症症状的影响，以及在治疗应用中的可能用途。
Effects of PACAP on Dry Eye Symptoms, and Possible Use for Therapeutic Application.
机构信息
Global Research Center for Innovative Life Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
Department of Anatomy and Ophthalmology, Showa University School of Medicine, Shinagawa-Ku, Tokyo, 142-8555, Japan.
出版信息
J Mol Neurosci. 2019 Jul;68(3):420-426. doi: 10.1007/s12031-018-1087-1. Epub 2018 Jun 22.
PMID:29931503
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family of peptides. PACAP and its three receptor subtypes are expressed in neural tissues and in the eye, including the retina, cornea, and lacrimal gland. PACAP is known to exert pleiotropic effects on the central nervous system and in eye tissues where it plays important roles in protecting against dry eye. This review provides an overview of current knowledge regarding dry eye symptoms in aged animals and humans and the protective effects, mechanisms of action. In addition, we also refer to the development of a new preventive/therapeutic method by PACAP of dry eye patients.
摘要
垂体腺苷酸环化酶激活肽（PACAP）是一种 27 或 38 个氨基酸的神经肽，属于血管活性肠肽/胰高血糖素/分泌素家族的肽。PACAP 及其三种受体亚型在神经组织和眼睛中表达，包括视网膜、角膜和泪腺。已知 PACAP 对中枢神经系统和眼部组织具有多种作用，在保护眼睛免受干眼症方面发挥着重要作用。本综述概述了目前关于老年动物和人类干眼症症状以及保护作用、作用机制的知识。此外，我们还提到了通过 PACAP 开发干眼症患者新的预防/治疗方法的进展。
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