Suppr超能文献

(-)-表儿茶素可降低去氧皮质酮醋酸盐高血压大鼠的血压并改善左心室功能和顺应性。

(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

机构信息

School of Health and Biomedical Science, RMIT University, Bundoora, VIC 3083, Australia.

School of Health, Medical and Applied Sciences, CQUniversity Australia, Rockhampton, QLD 4071, Australia.

出版信息

Molecules. 2018 Jun 22;23(7):1511. doi: 10.3390/molecules23071511.

Abstract

(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study investigated the effect of 28 days of low epicatechin dosing (1 mg/kg/day) on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Wistar rats (n = 120, 8 weeks of age) underwent uninephrectomy and were randomised into four groups (uninephrectomy (UNX), UNX + E, DOCA, DOCA + E). DOCA and DOCA + E rats received 1% NaCl drinking water along with subcutaneous injections of 25 mg deoxycorticosterone-acetate (in 0.4 mL of dimethylformamide) every fourth day. UNX + E and DOCA + E rats received 1 mg/kg/day of epicatechin by oral gavage. Single-cell micro-electrode electrophysiology, Langendorff isolated-heart assessment and isolated aorta and mesenteric organ baths were used to assess cardiovascular parameters. Serum malondialdehyde concentration was used as a marker of oxidative stress. Myocardial stiffness was increased and left ventricular compliance significantly diminished in the DOCA control group, and these changes were attenuated by epicatechin treatment ( < 0.05). Additionally, the DOCA + E rats showed significantly reduced blood pressure and malondialdehyde concentrations; however, there was no improvement in left ventricular hypertrophy, electrophysiology or vascular function. This study demonstrates the ability of epicatechin to reduce blood pressure, prevent myocardial stiffening and preserve cardiac compliance in hypertrophied DOCA-salt rat hearts.

摘要

(−)-表儿茶素(E)是一种存在于绿茶和可可中的黄烷醇,已被证明可减轻肿瘤坏死因子α(TNF-α)介导的炎症,提高一氧化氮水平,促进内皮型一氧化氮合酶(eNOS)的激活,并抑制 NADPH 氧化酶。本研究调查了 28 天低表儿茶素剂量(1mg/kg/天)对去氧皮质酮醋酸盐(DOCA)-盐高血压大鼠心血管功能的影响。Wistar 大鼠(n=120,8 周龄)接受单侧肾切除术,并随机分为四组(单侧肾切除术(UNX)、UNX+E、DOCA、DOCA+E)。DOCA 和 DOCA+E 组给予 1%NaCl 饮用水,并每隔四天皮下注射 25mg 去氧皮质酮醋酸盐(溶于 0.4ml 二甲基甲酰胺)。UNX+E 和 DOCA+E 组通过口服灌胃给予 1mg/kg/天的表儿茶素。单细胞微电极电生理学、Langendorff 分离心脏评估以及分离的主动脉和肠系膜器官浴用于评估心血管参数。血清丙二醛浓度用作氧化应激的标志物。在 DOCA 对照组中,心肌僵硬度增加,左心室顺应性显著降低,表儿茶素治疗可减轻这些变化(<0.05)。此外,DOCA+E 组的血压和丙二醛浓度明显降低;然而,左心室肥厚、电生理学或血管功能没有改善。本研究表明,表儿茶素能够降低血压,防止心肌僵硬并保持肥厚 DOCA-盐大鼠心脏的顺应性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1f1/6100191/57e62e1d7ed8/molecules-23-01511-g001.jpg

相似文献

4
Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.
Br J Pharmacol. 2006 Aug;148(7):902-8. doi: 10.1038/sj.bjp.0706801. Epub 2006 Jun 19.
5
Reversal of cardiac dysfunction by selective ET-A receptor antagonism.
Br J Pharmacol. 2005 Nov;146(6):846-53. doi: 10.1038/sj.bjp.0706384.
6
8
Cardiac and vascular responses in deoxycorticosterone acetate-salt hypertensive rats.
Clin Exp Pharmacol Physiol. 2000 Apr;27(4):263-9. doi: 10.1046/j.1440-1681.2000.03234.x.
10

引用本文的文献

1
Cardiovascular Effects, Antioxidant Activity, and Phytochemical Analysis of Schott Leaves.
Plants (Basel). 2025 Aug 12;14(16):2513. doi: 10.3390/plants14162513.
2
Central nervous system mechanisms of salt-sensitive hypertension.
Physiol Rev. 2025 Oct 1;105(4):1989-2032. doi: 10.1152/physrev.00035.2024. Epub 2025 May 2.
4
Effects of epicatechin on cardiovascular function in middle-aged diet-induced obese rat models of metabolic syndrome.
Br J Nutr. 2024 Feb 28;131(4):593-605. doi: 10.1017/S000711452300209X. Epub 2023 Sep 21.
5
Oxidative Stress, Antioxidants and Hypertension.
Antioxidants (Basel). 2023 Jan 27;12(2):281. doi: 10.3390/antiox12020281.
7
Green tea and metabolic syndrome: A 10-year research update review.
Iran J Basic Med Sci. 2021 Sep;24(9):1159-1172. doi: 10.22038/IJBMS.2021.52980.11943.
9
Arginase inhibition by (-)-Epicatechin reverses endothelial cell aging.
Eur J Pharmacol. 2020 Oct 15;885:173442. doi: 10.1016/j.ejphar.2020.173442. Epub 2020 Aug 11.
10
Effect of cocoa powder on hypertension and antioxidant status in uninephrectomized hypertensive rats.
Vet World. 2019 Apr;13(4):695-705. doi: 10.14202/vetworld.2020.695-705. Epub 2020 Apr 16.

本文引用的文献

1
Epicatechin's cardiovascular protective effects are mediated via opioid receptors and nitric oxide.
Eur J Nutr. 2019 Mar;58(2):515-527. doi: 10.1007/s00394-018-1650-0. Epub 2018 May 10.
2
LPS-induced renal inflammation is prevented by (-)-epicatechin in rats.
Redox Biol. 2017 Apr;11:342-349. doi: 10.1016/j.redox.2016.12.023. Epub 2016 Dec 22.
3
(-)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice.
Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600343. Epub 2016 Oct 10.
5
Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function.
Int J Cardiol. 2014 Aug 1;175(2):297-306. doi: 10.1016/j.ijcard.2014.05.009. Epub 2014 May 15.
8
(-)-Epicatechin-induced calcium independent eNOS activation: roles of HSP90 and AKT.
Mol Cell Biochem. 2012 Nov;370(1-2):141-50. doi: 10.1007/s11010-012-1405-9. Epub 2012 Aug 3.
9
Cardiac sympathetic hyperinnervation in deoxycorticosterone acetate-salt hypertensive rats.
Clin Sci (Lond). 2012 Oct;123(7):445-57. doi: 10.1042/CS20120080.
10
(-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes.
Arch Biochem Biophys. 2012 Nov 15;527(2):113-8. doi: 10.1016/j.abb.2012.02.019. Epub 2012 Mar 8.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验