Centre for Rehabilitation Engineering, Biomedical Engineering Division, School of Engineering, University of Glasgow, Glasgow, UK.
Centre for Rehabilitation Engineering, Biomedical Engineering Division, School of Engineering, University of Glasgow, Glasgow, UK; Technical Engineering College of Mosul, Northern Technical University, Mosul, Iraq.
Clin Neurophysiol. 2018 Aug;129(8):1669-1679. doi: 10.1016/j.clinph.2018.05.020. Epub 2018 Jun 15.
Spinal Cord Injured (SCI) persons with and without Central Neuropathic Pain (CNP) show different oscillatory brain activities during imagination of movement. This study investigates whether they also show differences in movement related cortical potentials (MRCP).
SCI paraplegic patients with no CNP (n = 8), with CNP in their lower limbs (n = 8), and healthy control subjects (n = 10) took part in the study. EEG clustering involved independent component analysis, equivalent current dipole fitting, and Measure Projection to define cortical domains that have functional modularity during the motor imagery task.
Three domains were identified: limbic system, sensory-motor cortex and visual cortex. The MRCP difference between the groups of SCI with and without CNP was reflected in a domain located in the limbic system, while the difference between SCI patients and control subjects was in the sensorimotor domain. Differences in MRCP morphology between patients and healthy controls were visible for both paralysed and non paralysed limbs.
SCI but not CNP affects the movement preparation, and both SCI and CNP affect sensory processes.
Rehabilitation strategies of SCI patients based on MRCP should take into account the presence of CNP.
脊髓损伤（SCI）伴有和不伴有中枢性神经病理性疼痛（CNP）的患者在想象运动时表现出不同的脑振荡活动。本研究旨在探讨他们在运动相关皮质电位（MRCP）上是否也存在差异。
本研究纳入了 8 名无 CNP 的 SCI 截瘫患者、8 名下肢有 CNP 的 SCI 患者和 10 名健康对照组受试者。EEG 聚类涉及独立成分分析、等效电流偶极拟合和 Measure Projection，以定义在运动想象任务中具有功能模块化的皮质域。
共鉴定出 3 个域：边缘系统、感觉运动皮质和视觉皮质。有和无 CNP 的 SCI 组之间的 MRCP 差异反映在边缘系统的一个域中，而 SCI 患者与对照组之间的差异则在感觉运动域中。在瘫痪和非瘫痪肢体上都可以看到患者与健康对照组之间的 MRCP 形态差异。
SCI 而不是 CNP 影响运动准备，而 SCI 和 CNP 都会影响感觉过程。
基于 MRCP 的 SCI 患者康复策略应考虑 CNP 的存在。
