白细胞介素-17A和F基因多态性影响结核病风险：一项更新的荟萃分析。

Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis.

作者信息

Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Tahmasebi Arezoo, Asadi-Saghandi Abolghasem

机构信息

Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Indian J Tuberc. 2018 Jul;65(3):200-207. doi: 10.1016/j.ijtb.2017.08.027. Epub 2017 Sep 27.

DOI:10.1016/j.ijtb.2017.08.027

PMID:29933861

Abstract

BACKGROUND

Cytokines are fundamental elements in mediating and stimulating the immune response against tuberculosis (TB). Growing evidence indicated that polymorphisms in the interleukin-17 (IL-17) A and F genes are implicated in TB.

OBJECTIVES

This meta-analysis was aimed to re-evaluate and update the relationship between IL-17A rs2275913 G/A and IL17F rs763780 T/C polymorphisms and TB risk.

METHODS

Using inclusive searches of the PubMed, MEDLINE, EMBASE, Web of Science and Elsevier Science Direct, we identified outcome data from all articles estimating the association between IL-17 A and F polymorphisms and TB risk.

RESULTS

A total of 15 studies comprising 7130 patients and 7540 controls were included. Our pooled analysis demonstrated that the IL-17A rs2275913 G/A SNP was not associated with the risk of TB in overall, or in Asians and Caucasians, but it conferred resistance to TB in Latin Americans using allele (OR=0.53), codominant (OR=0.53 and 0.38), dominant (OR=0.49) and recessive (OR=0.46) inheritance models. For IL-17F rs763780 T/C, the pooled evidence indicated that this variation was a risk factor for TB in allele (C vs T) and dominant (TC+CC vs TT) models in overall (OR of 1.35) and among Asians (OR=1.40), but not in Caucasians.

CONCLUSION

In summary, our meta-analysis suggested that the IL-17A rs2275913 was a protective factor against TB, but -17F rs763780 T/C was a risk factor for TB.

摘要

背景

细胞因子是介导和刺激抗结核免疫反应的基本要素。越来越多的证据表明，白细胞介素-17（IL-17）A和F基因的多态性与结核病有关。

目的

本荟萃分析旨在重新评估和更新IL-17A rs2275913 G/A和IL17F rs763780 T/C多态性与结核病风险之间的关系。

方法

通过对PubMed、MEDLINE、EMBASE、科学引文索引和爱思唯尔科学Direct进行全面检索，我们从所有文章中确定了估计IL-17 A和F多态性与结核病风险之间关联的结果数据。

结果

共纳入15项研究，包括7130例患者和7540例对照。我们的汇总分析表明，IL-17A rs2275913 G/A单核苷酸多态性在总体上，或在亚洲人和高加索人中与结核病风险无关，但在拉丁美洲人中，使用等位基因（OR=0.53）、共显性（OR=0.53和0.38）、显性（OR=0.49）和隐性（OR=0.46）遗传模型时，它赋予了对结核病的抗性。对于IL-17F rs763780 T/C，汇总证据表明，在总体上（OR为1.35）和亚洲人（OR=1.40）中，该变异在等位基因（C与T）和显性（TC+CC与TT）模型中是结核病的危险因素，但在高加索人中不是。