Centro de Estudios e Investigación de la Enfermedad de Chagas y Leishmaniasis, FCM, INICSA-CONICET-UNC, Córdoba, Argentina.
Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, España.
Sci Rep. 2020 Mar 19;10(1):5015. doi: 10.1038/s41598-020-61965-5.
Genetic factors and the immunologic response have been suggested to determine the susceptibility against the infection and the outcome of Chagas disease. In the present study, we analysed three IL17A genetic variants (rs4711998, rs8193036 and rs2275913) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC) in different Latin American populations. A total of 2,967 individuals from Colombia, Argentina, Bolivia and Brazil, were included in this study. The individuals were classified as seronegative and seropositive for T. cruzi antigens, and this last group were divided into asymptomatic and CCC. For T. cruzi infection susceptibility, the IL17A rs2275913*A showed a significant association in a fixed-effect meta-analysis after a Bonferroni correction (P = 0.016, OR = 1.21, 95%CI = 1.06-1.41). No evidence of association was detected when comparing CCC vs. asymptomatic patients. However, when CCC were compared with seronegative individuals, it showed a nominal association in the meta-analysis (P = 0.040, OR = 1.20, 95%CI = 1.01-1.45). For the IL17A rs4711998 and rs8193036, no association was observed. In conclusion, our results suggest that IL17A rs2275913 plays an important role in the susceptibility to T. cruzi infection and could also be implicated in the development of chronic cardiomyopathy in the studied Latin American population.
遗传因素和免疫反应被认为决定了对感染的易感性和恰加斯病的结局。在本研究中，我们分析了三个 IL17A 基因变异（rs4711998、rs8193036 和 rs2275913），以探讨它们在不同拉丁美洲人群中对克氏锥虫感染的易感性和慢性恰加斯心肌病（CCC）的发展的作用。本研究共纳入了来自哥伦比亚、阿根廷、玻利维亚和巴西的 2967 名个体。这些个体被分为血清阴性和血清阳性的克氏锥虫抗原，后者又分为无症状和 CCC。对于克氏锥虫感染的易感性，在经过 Bonferroni 校正的固定效应荟萃分析中，IL17A rs2275913*A 显示出显著的相关性（P=0.016，OR=1.21，95%CI=1.06-1.41）。在比较 CCC 与无症状患者时，没有发现相关性。然而，在将 CCC 与血清阴性个体进行比较时，荟萃分析显示出了名义上的相关性（P=0.040，OR=1.20，95%CI=1.01-1.45）。对于 IL17A rs4711998 和 rs8193036，没有观察到相关性。总之，我们的结果表明，IL17A rs2275913 在克氏锥虫感染的易感性中起着重要作用，并且可能与所研究的拉丁美洲人群中慢性心肌病的发展有关。
