Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan.
Taipei City Psychiatric Center, Taipei City Hospital, Addiction Psychiatry Department, Taipei, Taiwan.
J Formos Med Assoc. 2018 Dec;117(12):1124-1127. doi: 10.1016/j.jfma.2018.06.005. Epub 2018 Jun 19.
Gamma-hydroxybutyrate (GHB) is a synthetic drug used mainly for recreational purpose. Although the prevalence of GHB abuse is low in Taiwan, GHB has become increasingly popular in certain subpopulations such as clubbers and men who have sex with men (MSM). GHB dependence could be associated with severe withdrawal syndrome including hallucinations and delirium. Despite systematic studies on detoxification and management of GHB withdrawal have been performed, no validated measurement for severity of GHB withdrawal syndrome is available. Here we present a case of GHB withdrawal delirium that was treated successfully with fixed and symptom-triggered benzodiazepine dosing regimen based on Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) scale. The utilization of CIWA-Ar in such cases could offer useful guidance for benzodiazepine dosing. To the best of our knowledge, this is the first case report of GHB withdrawal delirium in Taiwan.
γ-羟基丁酸（GHB）是一种主要用于娱乐目的的合成药物。尽管 GHB 滥用在台湾的流行程度较低，但 GHB 在某些亚人群中（如夜店常客和男男性行为者）越来越受欢迎。GHB 依赖可能与严重的戒断综合征有关，包括幻觉和谵妄。尽管已经对 GHB 戒断的解毒和管理进行了系统研究，但目前尚无有效的 GHB 戒断综合征严重程度的测量方法。在这里，我们报告了一例 GHB 戒断性谵妄病例，该病例成功地采用了基于临床戒断评估酒精修订版（CIWA-Ar）量表的固定和症状触发苯二氮䓬类药物剂量方案进行治疗。CIWA-Ar 在这种情况下的使用可以为苯二氮䓬类药物的剂量提供有用的指导。据我们所知，这是台湾首例 GHB 戒断性谵妄的病例报告。
