University of Illinois, Chicago, IL, United States; School of Life Science, Central South University, Changsha, China.
School of Life Science, Central South University, Changsha, China.
Prog Mol Biol Transl Sci. 2018;157:175-232. doi: 10.1016/bs.pmbts.2018.01.006. Epub 2018 Apr 11.
DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review the mechanisms of DNA methylation, including the genetic and environmental factors affecting methylation changes. We report and discuss major findings regarding DNA methylation in psychiatric patients, both within the context of global methylation studies and gene-specific methylation studies. Finally, we discuss issues surrounding data quality improvement, the limitations of current methylation analysis methods, and the possibility of using DNA methylation-based treatment for psychiatric disorders in the future.
DNA 甲基化一直是精神疾病分子机制研究的一个重要领域。最近的证据表明，整体甲基化、基因甲基化和通路的异常可能在许多形式的精神疾病的病因中起作用。在本文中，我们综述了 DNA 甲基化的机制，包括影响甲基化变化的遗传和环境因素。我们报告并讨论了精神疾病患者的 DNA 甲基化的主要发现，包括整体甲基化研究和基因特异性甲基化研究的结果。最后，我们讨论了围绕数据质量改进、当前甲基化分析方法的局限性以及未来基于 DNA 甲基化的精神疾病治疗的可能性等问题。
