解析巨噬细胞激活的激酶图谱。
MAPping the kinase landscape of macrophage activation.
机构信息
From the Department of Medicine, Division of Nephrology, McMaster University, St. Joseph's Healthcare Hamilton and Hamilton Center for Kidney Research, Hamilton, Ontario L8N 4A6 and.
From the Department of Medicine, Division of Nephrology, McMaster University, St. Joseph's Healthcare Hamilton and Hamilton Center for Kidney Research, Hamilton, Ontario L8N 4A6 and
出版信息
J Biol Chem. 2018 Jun 22;293(25):9910-9911. doi: 10.1074/jbc.H118.003380.
Abstract
ARL11 is a tumor suppressor gene with established pro-apoptotic properties, but its function beyond this role is poorly understood. A new analysis of macrophage activation has identified ARL11 as a novel regulator of a mitogen-activated protein kinase (MAPK). These findings expand on the function of ARL11 beyond its tumor suppressor activity and highlight a novel role as a regulator of macrophage activation and inflammatory response.
摘要
ARL11 是一种具有明确促凋亡特性的肿瘤抑制基因，但人们对其功能知之甚少。对巨噬细胞激活的新分析确定 ARL11 是丝裂原活化蛋白激酶（MAPK）的新型调节剂。这些发现扩展了 ARL11 的功能，超出了其肿瘤抑制活性，并强调了其作为巨噬细胞激活和炎症反应调节剂的新作用。
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