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Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.谷氨酰胺酶GLS1以非酶促方式感知谷氨酰胺可用性，从而触发线粒体融合。
Cell Res. 2018 Aug;28(8):865-867. doi: 10.1038/s41422-018-0057-z. Epub 2018 Jun 22.
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Regulation of glutaminase activity and glutamine metabolism.谷氨酰胺酶活性与谷氨酰胺代谢的调节
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T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions.在缺氧和常氧条件下，辅助性T细胞的激活和扩增对谷氨酰胺酶抑制敏感。
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Comprehensive analysis of ammonia-induced cell death and GLS1 in gastric adenocarcinoma: implications for prognosis and therapeutic strategies.氨诱导的细胞死亡和谷氨酰胺酶1在胃腺癌中的综合分析：对预后和治疗策略的意义
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Front Oncol. 2025 Aug 20;15:1485006. doi: 10.3389/fonc.2025.1485006. eCollection 2025.
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Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome.谷氨酸脱氢酶1依赖性α-酮戊二酸通过调节共价闭合环状DNA微型染色体上的组蛋白甲基化促进乙型肝炎病毒转录。
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Transmembrane Amino Acid Transporters in Shaping the Metabolic Profile of Breast Cancer Cell Lines: The Focus on Molecular Biological Subtype.跨膜氨基酸转运体在塑造乳腺癌细胞系代谢谱中的作用：聚焦分子生物学亚型
Curr Issues Mol Biol. 2024 Dec 25;47(1):4. doi: 10.3390/cimb47010004.
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LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review.长链非编码RNA介导的代谢重编程：实体瘤恶性进展的主要元凶：最新综述
Nutr Metab (Lond). 2024 Nov 8;21(1):89. doi: 10.1186/s12986-024-00866-0.
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Asparagine Availability Is a Critical Limiting Factor for Infectious Spleen and Kidney Necrosis Virus Replication.天冬酰胺可用性是传染性脾肾坏死病毒复制的关键限制因素。
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IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages.IDH2 通过调节巨噬细胞中线粒体代谢来调控巨噬细胞极化和肿瘤发生。
Mol Med. 2024 Sep 10;30(1):143. doi: 10.1186/s10020-024-00911-x.
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Homeostatic regulation of NAD(H) and NADP(H) in cells.细胞中NAD(H)和NADP(H)的稳态调节。
Genes Dis. 2023 Oct 17;11(5):101146. doi: 10.1016/j.gendis.2023.101146. eCollection 2024 Sep.

本文引用的文献

1
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.癌细胞代谢：非必需氨基酸谷氨酰胺的重要作用。
EMBO J. 2017 May 15;36(10):1302-1315. doi: 10.15252/embj.201696151. Epub 2017 Apr 18.
2
Metabolic regulation of mitochondrial dynamics.线粒体动力学的代谢调控
J Cell Biol. 2016 Feb 15;212(4):379-87. doi: 10.1083/jcb.201511036. Epub 2016 Feb 8.
3
Mitochondrial Dynamics and Metabolic Regulation.线粒体动态与代谢调控。
Trends Endocrinol Metab. 2016 Feb;27(2):105-117. doi: 10.1016/j.tem.2015.12.001. Epub 2016 Jan 2.
4
Glutaminases in brain: Multiple isoforms for many purposes.大脑中的谷氨酰胺酶：多种同工型，用途广泛。
Neurochem Int. 2015 Sep;88:1-5. doi: 10.1016/j.neuint.2015.03.006. Epub 2015 Mar 30.
5
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.Opa1的蛋白水解切割刺激线粒体内膜融合，并将融合与氧化磷酸化偶联起来。
Cell Metab. 2014 Apr 1;19(4):630-41. doi: 10.1016/j.cmet.2014.03.011.
6
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).人肾型谷氨酰胺酶（KGA）活性位点抑制机制的结构基础。
Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827.
7
Glutamine and cancer: cell biology, physiology, and clinical opportunities.谷氨酰胺与癌症：细胞生物学、生理学和临床机遇。
J Clin Invest. 2013 Sep;123(9):3678-84. doi: 10.1172/JCI69600. Epub 2013 Sep 3.
8
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.谷氨酰胺通过 KRAS 调节的代谢途径支持胰腺癌生长。
Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27.
9
The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.PP2A 的 B55α 亚基驱动依赖于 p53 的代谢适应来应对谷氨酰胺缺乏。
Mol Cell. 2013 Apr 25;50(2):200-11. doi: 10.1016/j.molcel.2013.02.008. Epub 2013 Mar 14.
10
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.人源肾型谷氨酰胺酶（KGA）变构抑制机制的结构基础及其在肿瘤细胞代谢中受 Raf-Mek-Erk 信号通路的调控。
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7705-10. doi: 10.1073/pnas.1116573109. Epub 2012 Apr 26.

Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.

作者信息

Cai Wei-Feng, Zhang Cixiong, Wu Yu-Qing, Zhuang Gui, Ye Zhiyun, Zhang Chen-Song, Lin Sheng-Cai

机构信息

State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian, 361102, China.

出版信息

Cell Res. 2018 Aug;28(8):865-867. doi: 10.1038/s41422-018-0057-z. Epub 2018 Jun 22.

DOI:10.1038/s41422-018-0057-z
PMID:29934617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6082853/
Abstract
摘要