Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
作者信息
Cai Wei-Feng, Zhang Cixiong, Wu Yu-Qing, Zhuang Gui, Ye Zhiyun, Zhang Chen-Song, Lin Sheng-Cai
机构信息
State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian, 361102, China.
出版信息
Cell Res. 2018 Aug;28(8):865-867. doi: 10.1038/s41422-018-0057-z. Epub 2018 Jun 22.
Abstract
摘要
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EMBO J. 2017 May 15;36(10):1302-1315. doi: 10.15252/embj.201696151. Epub 2017 Apr 18.
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Metabolic regulation of mitochondrial dynamics.线粒体动力学的代谢调控
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Mitochondrial Dynamics and Metabolic Regulation.线粒体动态与代谢调控。
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Glutaminases in brain: Multiple isoforms for many purposes.大脑中的谷氨酰胺酶：多种同工型，用途广泛。
Neurochem Int. 2015 Sep;88:1-5. doi: 10.1016/j.neuint.2015.03.006. Epub 2015 Mar 30.
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Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.Opa1的蛋白水解切割刺激线粒体内膜融合，并将融合与氧化磷酸化偶联起来。
Cell Metab. 2014 Apr 1;19(4):630-41. doi: 10.1016/j.cmet.2014.03.011.
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Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).人肾型谷氨酰胺酶（KGA）活性位点抑制机制的结构基础。
Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827.
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Glutamine and cancer: cell biology, physiology, and clinical opportunities.谷氨酰胺与癌症：细胞生物学、生理学和临床机遇。
J Clin Invest. 2013 Sep;123(9):3678-84. doi: 10.1172/JCI69600. Epub 2013 Sep 3.
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.谷氨酰胺通过 KRAS 调节的代谢途径支持胰腺癌生长。
Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27.
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The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.PP2A 的 B55α 亚基驱动依赖于 p53 的代谢适应来应对谷氨酰胺缺乏。
Mol Cell. 2013 Apr 25;50(2):200-11. doi: 10.1016/j.molcel.2013.02.008. Epub 2013 Mar 14.
10
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.人源肾型谷氨酰胺酶（KGA）变构抑制机制的结构基础及其在肿瘤细胞代谢中受 Raf-Mek-Erk 信号通路的调控。
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7705-10. doi: 10.1073/pnas.1116573109. Epub 2012 Apr 26.
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