Institute of Physiology and Anatomy, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Bundeswehr Institute for Preventive Medicine, Aktienstraße 87, 56626, Andernach, Germany.
Eur J Appl Physiol. 2018 Sep;118(9):1845-1856. doi: 10.1007/s00421-018-3916-x. Epub 2018 Jun 22.
The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO) kinetics at the pulmonary (avDOpulm) and muscle (avDOmusc) levels is significantly different during dynamic exercise.
A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDOpulm and avDOmusc.
A significant difference between [Formula: see text] (0.395 ± 0.079) and [Formula: see text] kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (r = 0.744, p < 0.001). There were no significant differences between avDOmusc (0.446 ± 0.077) and avDOpulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001).
It is suggested that neither avDOpulm nor avDOmusc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.
本研究旨在测试在动态运动过程中，肺（avDOpulm）和肌肉（avDOmusc）水平的动静脉血氧浓度差（avDO）动力学是否存在显著差异。
利用涉及 6 篇文献的再分析，对总共 69 名参与者的样本量进行了研究。所有研究均采用相同的伪随机二进制序列工作率（WR）方案-WR 在 30 至 80 W 之间变化-以分析肺（[Formula: see text]）和肌肉（[Formula: see text]）摄氧量动力学以及 avDOpulm 和 avDOmusc 的动力学反应。
观察到[Formula: see text]（0.395 ± 0.079）和[Formula: see text]动力学（0.330 ± 0.078）之间存在显著差异（p < 0.001），其中变量呈显著相关关系（r = 0.744，p < 0.001）。avDOmusc（0.446 ± 0.077）和 avDOpulm 动力学（0.451 ± 0.075）之间无显著差异，两者高度相关（r = 0.929，p < 0.001）。
研究表明，avDOpulm 和 avDOmusc 的动力学反应似乎都不会导致估计的[Formula: see text]和实测的[Formula: see text]动力学之间的差异。显然，在不同的时间点和不同的生理水平上，avDO 和灌注（[Formula: see text]）的融合导致了[Formula: see text]和[Formula: see text]动力学之间的潜在差异。因此，在分析或讨论摄氧量动力学时，通常应考虑[Formula: see text]。
