Urdu speaking population from South India: Six extended haplotypes in linkage disequilibrium in Urdu Speaking Population.

B

C:DRB1:DQB1 allele and haplotype frequencies were determined among Urdu speaking population from South India by Sanger and Next Generation Sequencing. Seventy bone marrow registry donors and 327 cord blood units from the Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu were included in the study. No overall deviations from expected Hardy-Weinberg equilibrium proportions were observed at all the five loci studied. The most frequent HLA class I alleles observed in this population were A11:01:01, B40:06:01, and C06:02:01, showing a frequency of 15.87%, 12.72%, and 13.22%, respectively. The most frequent class II alleles observed in this population were DRB107:01:01 (15.62%) and DQB106:01:01 (21.41%). The top ranked haplotype A01:01:01B*57:01:01C06:02:01~DRB107:01:01~DQB1*03:03:02 (2.77%) reported in the present study, was the highly frequent haplotype found in Telugu speaking population who lived in the same region.