Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam, India.
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl 796017, Mizoram, India.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):397-405. doi: 10.1016/j.ijbiomac.2018.06.086. Epub 2018 Jun 21.
The objective of the present work is to study the physicochemical and functional properties of taro starch (Colocasia esculenta) and to further modify the starch by treating with citric acid to obtain a novel functional material. DSC, FTIR and SEM studies were performed along with physicochemical analysis. The disintegrant efficiency ratio and dissolution efficiency were determined on paracetamol tablets prepared by wet granulation taking the starch as a binder-disintegrant. The moisture content and ash values of taro and citrate taro starches were about 13% and 0.5% respectively. The average particle size of taro starch was found to be 1.53 μm and citration was not found to cause significant changes in the particle size. Results from disintegration efficiency study showed that both the taro and citrate modified taro starch showed tablet disintegrant property and even performed better than the standard corn starch. The reduced disintegration time was also found to enhance dissolution of the model drug from the tablet.
本工作旨在研究芋艿淀粉（Colocasia esculenta）的物理化学和功能特性，并通过用柠檬酸处理进一步修饰淀粉，以获得一种新型的功能性材料。进行了 DSC、FTIR 和 SEM 研究以及物理化学分析。通过湿法制粒法制备对乙酰氨基酚片，以淀粉作为粘合剂-崩解剂，测定崩解剂效率比和溶出效率。芋艿淀粉和柠檬酸芋艿淀粉的水分含量和灰分含量分别约为 13%和 0.5%。芋艿淀粉的平均粒径为 1.53μm，而柠檬酸化并未导致粒径发生显著变化。崩解效率研究结果表明，芋艿淀粉和柠檬酸修饰的芋艿淀粉均表现出片剂崩解剂的特性，甚至比标准玉米淀粉表现更好。还发现，崩解时间的缩短也能促进模型药物从片剂中的溶解。
