Department of Laboratory, People's Hospital of Yuxi City, 21 Nieer Road, Yuxi City, Yunnan Province 653100, PR China.
Intensive Care Unit, People's Hospital of Yuxi City, 21 Nieer Road, Yuxi City, Yunnan Province 653100, PR China.
Diabetes Res Clin Pract. 2018 Aug;142:353-362. doi: 10.1016/j.diabres.2018.06.011. Epub 2018 Jun 22.
To verify the correlations between HbA1c and fasting glucose levels.
A cross-sectional study with 14,249 Chinese subjects. Objective was evaluated in pooled, age-stratified, HbA1c and fasting glucose-stratified populations.
In pooled populations, the Pearson correlation coefficients (PCCs) of males and females were 0.684 (P < 0.001) and 0.800 (P < 0.001), respectively. HbA1c and fasting glucose maintained significant correlations within the group with HbA1c < 6.5% and glucose <7.0 mmol/L and the group with HbA1c ≥ 6.5% and glucose ≥7.0 mmol/L in both males (PCC: 0.342, P < 0.001; and PCC: 0.765, P < 0.001, respectively) and females (PCC: 0.318, P < 0.001 and PCC: 0.788, P < 0.001, respectively). The slopes increased from the group with HbA1c < 6.5% and glucose <7.0 mmol/L to the group with HbA1c ≥ 6.5% and glucose ≥7.0 mmol/L in both males (0.26-0.44) and females (0.31-0.46). Linear regression analysis showed that fasting glucose and age were two common factors positively associated with HbA1C, and red blood cell count and red cell distribution width were two common factors negatively associated with HbA1c in both males and females with HbA1c < 6.5% and glucose <7.0 mmol/L. The correlations changed dramatically in the groups with HbA1c ≥ 6.5% and glucose <7.0 mmol/L and HbA1c < 6.5% and glucose ≥7.0 mmol/L.
High HbA1c and fasting glucose levels greatly altered the associations between HbA1c, glucose and age.
验证糖化血红蛋白（HbA1c）与空腹血糖水平之间的相关性。
这是一项包含 14249 名中国受试者的横断面研究。在汇总人群、年龄分层人群、HbA1c 和空腹血糖分层人群中评估了研究目标。
在汇总人群中，男性和女性的 Pearson 相关系数（PCC）分别为 0.684（P<0.001）和 0.800（P<0.001）。在 HbA1c<6.5%且血糖<7.0mmol/L 的组内和 HbA1c≥6.5%且血糖≥7.0mmol/L 的组内，HbA1c 和空腹血糖之间均保持显著相关性，且在男性（PCC：0.342，P<0.001；PCC：0.765，P<0.001）和女性（PCC：0.318，P<0.001；PCC：0.788，P<0.001）中均如此。斜率从 HbA1c<6.5%且血糖<7.0mmol/L 的组增加到 HbA1c≥6.5%且血糖≥7.0mmol/L 的组，在男性（0.26-0.44）和女性（0.31-0.46）中均如此。线性回归分析表明，空腹血糖和年龄是与 HbA1c 呈正相关的两个共同因素，在 HbA1c<6.5%且血糖<7.0mmol/L 的男性和女性中，红细胞计数和红细胞分布宽度是与 HbA1c 呈负相关的两个共同因素。在 HbA1c≥6.5%且血糖<7.0mmol/L 组和 HbA1c<6.5%且血糖≥7.0mmol/L 组中，相关性发生了显著变化。
高 HbA1c 和空腹血糖水平极大地改变了 HbA1c、血糖和年龄之间的关系。
