采用艾姆斯试验、体外染色体试验及雌性小鼠微核试验对ST膜进行致突变性检测。

Mutagenicity testing of ST-film with the Ames test, chromosome test in vitro and micronucleus test in female mice.

作者信息

Shibuya T, Tanaka N, Katoh M, Matsuda Y T, Morita K

出版信息

J Toxicol Sci. 1985 May;10(2):135-41. doi: 10.2131/jts.10.135.

DOI:10.2131/jts.10.135

Abstract

The mutagenicity of ST-film and its components polyoxyethylenenonylether (NP-10) and polyvinylalcohol (PVAL) were studied by a reverse mutation test in S. typhimurium (Ames test), a chromosome test in cultured Chinese hamster V 79 cells and a micronucleus test in female mice. The results obtained from these test systems were all negative. Thus, it may be concluded that ST-film is not mutagenic either in vitro or in vivo mutagenicity testing systems.

摘要

通过鼠伤寒沙门氏菌回复突变试验（艾姆斯试验）、培养的中国仓鼠V79细胞染色体试验以及雌性小鼠微核试验，研究了ST膜及其成分聚氧乙烯壬基醚（NP - 10）和聚乙烯醇（PVAL）的致突变性。从这些试验系统获得的结果均为阴性。因此，可以得出结论，在体外和体内致突变性测试系统中，ST膜均无致突变性。