一种导致伏立康唑血药浓度假性升高的新原因：小心你的采集管！

A new cause of false positive voriconazole levels: Watch your collection tubes!

机构信息

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, Spain; Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.

Laboratory of Reference and Research on Mycology, National Center for Microbiology, Instituto de Salud Carlos III, Carretera de Majadahonda-Pozuelo Km. 2.200, 28220 Majadahonda, Spain.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:328-331. doi: 10.1016/j.jchromb.2018.06.022. Epub 2018 Jun 13.

DOI:10.1016/j.jchromb.2018.06.022

PMID:29936368

Abstract

We communicate the interference of a compound of the blood collection tube with the accuracy of a validated high-pressure liquid chromatography method with ultraviolet detection for quantifying voriconazole levels, which led to false positive results. This could have serious consequences for patient management. Our advice is to implement external assessment programs.

摘要

我们报道了一种血液采集管化合物对经过验证的高压液相色谱法-紫外检测定量伏立康唑浓度的准确性的干扰，导致假阳性结果。这可能对患者管理产生严重后果。我们建议实施外部评估计划。