接受手术的口咽癌患者中p16表达与预后的关系
Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery.
作者信息
Kida Kota, Terada Tomonori, Uwa Nobuhiro, Omori Yoshihiko, Fujii Takashi, Tomita Yasuhiko, Tsuzuki Kenzo, Nishikawa Hiroki, Sakagami Masafumi
机构信息
Department of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan
Department of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.
出版信息
In Vivo. 2018 Jul-Aug;32(4):927-935. doi: 10.21873/invivo.11331.
BACKGROUND/AIM: Prognostic impact of p16 expression in patients with oropharyngeal squamous cell carcinoma (OSCC) undergoing surgery is not fully examined. The aim of this study was to clarify these issues.
PATIENTS AND METHODS
Sixty-four OSCC subjects were analyzed. Immuno-histochemical staining of p16, a surrogate marker for human papillomavirus (HPV), was performed histopathologically. Data were retrospectively analyzed according to p16 positivity and factors linked to prognosis were also analyzed.
RESULTS
No significant difference was observed in the prognosis between the p16-positive group (n=28) and the p16-negative group (n=36). In patients undergoing post-operative radiation, the p16-positive group (n=18) had a significantly better prognosis than the p16-negative group (n=6). On multivariate analysis, transoral surgery was a significant predictor of overall survival (p=0.0173).
CONCLUSION
Prognostic impact of p16 can be emphasized in a subgroup of OSCC patients undergoing surgery. Surgery with sufficient surgical margin may be chosen as the first treatment for HPV-negative OSCC in some cases.
背景/目的：手术治疗的口咽鳞状细胞癌（OSCC）患者中，p16表达的预后影响尚未得到充分研究。本研究旨在阐明这些问题。
患者与方法
分析64例OSCC患者。对人乳头瘤病毒（HPV）的替代标志物p16进行免疫组织化学染色，并进行组织病理学检查。根据p16阳性情况进行回顾性数据分析，并分析与预后相关的因素。
结果
p16阳性组（n = 28）和p16阴性组（n = 36）的预后无显著差异。在接受术后放疗的患者中，p16阳性组（n = 18）的预后明显优于p16阴性组（n = 6）。多因素分析显示，经口手术是总生存的显著预测因素（p = 0.0173）。
结论
在接受手术治疗的OSCC患者亚组中，可强调p16对预后的影响。在某些情况下，可选择具有足够手术切缘的手术作为HPV阴性OSCC的首选治疗方法。
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