Wang H, Hu R Y, Qian Y J, Wang C M, Xie K X, Chen L L, Pan D X, Zhang Y D, Bian Z, Guo Y, Fiona M, Yu L M, Li Z M, Chen Zhengming
Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Jun 10;39(6):810-815. doi: 10.3760/cma.j.issn.0254-6450.2018.06.022.
To explore the effect of BMI and waist circumference on diabetes of adults. After excluding participants with heart disease, stroke, cancer and diabetes at baseline study, 53 916 people aged 30-79 in the China Kadoorie Biobank (CKB) study from Tongxiang city of Zhejiang province were recruited. Cox regression model was used to estimate the hazards ratios () for the associations of baseline BMI and waist circumference with incident diabetes. Among 391 512 person-years of the follow-up program between 2004 and 2013 (median 7.26 years), a total of 944 men and 1 643 women were diagnosed as having diabetes. Compared to those with normal weight, after adjusting for known or potential factors, of both overweight and obesity in men for incident diabetes appeared as 2.72 (95: 2.47-2.99) and 6.27 (95: 5.33-7.36), respectively. The corresponding figures in women were 2.19 (95: 2.04-2.36) and 3.78 (95: 3.36-4.26). Compared to those with normal waist circumference, after adjusting for known or potential factors, of Ⅰgrade andⅡgrade in men for diabetes were 2.56 (95: 2.22-2.95) and 4.66 (95: 4.14-5.24), respectively. The corresponding figures in women were 1.99 (95: 1.80-2.21) and 3.16 (95: 2.90-3.44), respectively. Overweight, obesity and central obesity were all associated with the increased incident of diabetes. Strategies on diabetes prevention should include not only losing weight, but reducing waist circumference as well.
探讨体重指数（BMI）和腰围对成年人糖尿病的影响。在基线研究中排除患有心脏病、中风、癌症和糖尿病的参与者后，招募了来自浙江省桐乡市中国嘉道理生物银行（CKB）研究中的53916名30 - 79岁的人群。采用Cox回归模型估计基线BMI和腰围与新发糖尿病之间关联的风险比（HR）。在2004年至2013年的随访项目中（中位随访7.26年），共有391512人年，其中944名男性和1643名女性被诊断患有糖尿病。与体重正常者相比，在调整已知或潜在因素后，男性超重和肥胖者发生糖尿病的HR分别为2.72（95%CI：2.47 - 2.99）和6.27（95%CI：5.33 - 7.36）。女性相应的数字分别为2.19（95%CI：2.04 - 2.36）和3.78（95%CI：3.36 - 4.26）。与腰围正常者相比，在调整已知或潜在因素后，男性Ⅰ级和Ⅱ级腰围者患糖尿病的HR分别为2.56（95%CI：2.22 - 2.95）和4.66（95%CI：4.14 - 5.24）。女性相应的数字分别为1.99（95%CI：1.80 - 2.21）和3.16（95%CI：2.90 - 3.44）。超重、肥胖和中心性肥胖均与糖尿病发病率增加相关。糖尿病预防策略不仅应包括减重，还应包括减小腰围。
