Sandoughdaran Saleh, Malekzadeh Mona, Mohammad Esmaeil Mohammad Esmaeil
Department of Radiation Oncology, Shohada-e-Tajrish Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
Asian Pac J Cancer Prev. 2018 Jun 25;19(6):1617-1620. doi: 10.22034/APJCP.2018.19.6.1617.
Background: Axillary lymph node metastasis is the most important predictive factor for recurrence risk and survival in patients with invasive breast carcinoma. The aim of this study was to determine factors associated with metastatic involvement of axillary lymph nodes in Iranian women with early breast cancer. Methods: This article reports a retrospective study of 774 patients with T1-T2 breast cancer who underwent resection of the primary tumor and axillary staging by SLNB and/or ALND between 2005 and 2015 at our institution. Results: Of the 774 patients included in this study, 35.5% (275 cases) had axillary lymph node involvement at the time of diagnosis. Factors associated with nodal involvement in univariate analyses were tumor size, lymphovascular invasion (LVI), tumor grade, ER/PR status and HER2 expression. All factors identified with univariate analyses were entered into a multivariate logistic regression model and tumor size (OR= 3.01, CI 2.01–4.49, P <0.001), ER/PR positivity (OR = 1.74, CI 1.1.16–2.62, P = 0.007) and presence of LVI (OR = 3.3.8, CI 2.31–4.95, P <0.001) remained as independent predictors of axillary lymph node involvement .Conclusions: In conclusion, the results of this study suggests that positive hormonal receptor status, LVI and tumor size are predictive factors for ALNM in Iranian women with early breast cancer.
腋窝淋巴结转移是浸润性乳腺癌患者复发风险和生存的最重要预测因素。本研究的目的是确定伊朗早期乳腺癌女性腋窝淋巴结转移受累的相关因素。方法：本文报告了一项对774例T1-T2期乳腺癌患者的回顾性研究，这些患者于2005年至2015年在我们机构接受了原发肿瘤切除及通过前哨淋巴结活检（SLNB）和/或腋窝淋巴结清扫术（ALND）进行的腋窝分期。结果：本研究纳入的774例患者中，35.5%（275例）在诊断时存在腋窝淋巴结受累。单因素分析中与淋巴结受累相关的因素有肿瘤大小、淋巴管侵犯（LVI）、肿瘤分级、雌激素受体/孕激素受体（ER/PR）状态和人表皮生长因子受体2（HER2）表达。单因素分析确定的所有因素均纳入多因素逻辑回归模型，肿瘤大小（OR = 3.01，CI 2.01 - 4.49，P <0.001）、ER/PR阳性（OR = 1.74，CI 1.16 - 2.62，P = 0.007）和LVI的存在（OR = 3.8，CI 2.31 - 4.95，P <0.001）仍然是腋窝淋巴结受累的独立预测因素。结论：总之，本研究结果表明，激素受体阳性状态、LVI和肿瘤大小是伊朗早期乳腺癌女性腋窝淋巴结转移的预测因素。
