Quijano-Gomero E G, Rodríguez-Zúñiga M J M, Sanz-Montero M E, Durand-Buse D
Unidad de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú.
Unidad de Dermatología, Hospital Nacional Daniel Alcides Carrión, Callao, Perú; Universidad Nacional Mayor de San Marcos, Lima, Perú.
Actas Dermosifiliogr (Engl Ed). 2019 Sep;110(7):590-596. doi: 10.1016/j.ad.2017.12.012. Epub 2018 Jun 21.
Primary recurrent cutaneous eosinophilic vasculitis is a rare condition characterized by pruritic, erythematous, purpuric plaques associated to edema. We compared and analyze the clinical, dermoscopic and histological features of the disease in 4 patients from our hospital and 13 patients published in the literature. Seventeen patients were included, with a median age of 56yo, a median duration of disease of 6 months. Lesions were most frequently generalized (47%) or localized in lower limbs (41%). The most frequent features were purpuric color (71%), local edema (65%), necrotizing vasculitis (94%) and eosinophil infiltration (100%) in histology. Most of the patients (82.4%) were given oral steroids with a median dose of 30mg. Primary recurrent cutaneous eosinophilic vasculitis might be an infra-diagnosed condition. The analysis of the patients allowed us to propose diagnostic criteria for the definition of this disease. We suggest a therapeutic strategy with high-potency steroids and dapsone, which might be considered as first-line treatment.
原发性复发性皮肤嗜酸性血管炎是一种罕见疾病，其特征为伴有水肿的瘙痒性、红斑性、紫癜性斑块。我们对我院4例患者及文献报道的13例患者的该疾病临床、皮肤镜及组织学特征进行了比较和分析。共纳入17例患者，中位年龄56岁，疾病中位病程6个月。皮损最常见为泛发性（47%）或局限于下肢（41%）。组织学上最常见的特征为紫癜色（71%）、局部水肿（65%）、坏死性血管炎（94%）及嗜酸性粒细胞浸润（100%）。大多数患者（82.4%）接受了口服类固醇治疗，中位剂量为30mg。原发性复发性皮肤嗜酸性血管炎可能是一种诊断不足的疾病。对这些患者的分析使我们能够提出该疾病定义的诊断标准。我们建议采用高效类固醇和氨苯砜的治疗策略，可将其视为一线治疗方法。
