Huang Xue-Pei, Ye Tian-Tian, Zhang Li, Liu Rui-Feng, Lai Xing-Jian, Wang Liang, Yang Meng, Zhang Bo, Li Xiao-Yi, Liu Zi-Wen, Xia Yu, Jiang Yu-Xin
Department of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
Department of General Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.
Surg Oncol. 2018 Jun;27(2):172-176. doi: 10.1016/j.suronc.2018.03.004. Epub 2018 Mar 27.
To study the correlations between the sonographic features of papillary thyroid microcarcinoma (PTMC) and the presence of high-volume lymph node metastasis.
Medical records of 2363 PTMC patients were reviewed form October 2013 to December 2015. All the patients with lymph node metastasis identified by histopathology were included. Preoperative sonographic features, such as multifocality, tumour size, echogenicity, calcification, vascularity of papillary microcarcinoma, and capsule invasion, were recorded. Univariate and multivariate analyses were performed to investigate the relationships between sonographic features and high-volume lymph node metastasis (number of metastatic lymph nodes >5).
In total, 152 patients had high-volume central lymph node metastasis (6.4%, 152/2363). Multiple logistic regression analysis showed that the preoperative ultrasonic features of microcalcifications (OR = 3.33, p = 0.022), larger tumour size (>7 mm) (OR = 2.802, p < 0.001), and capsule invasion (OR = 2.141, p = 0.006) were independent risk factors for high-volume lymph node metastasis in the central compartment of PTMC.
The sonographic features of primary papillary microcarcinoma of the thyroid are correlated with high-volume central lymph node metastasis.
研究甲状腺微小乳头状癌（PTMC）的超声特征与高容量淋巴结转移之间的相关性。
回顾性分析2013年10月至2015年12月期间2363例PTMC患者的病历。纳入所有经组织病理学确诊有淋巴结转移的患者。记录术前超声特征，如多灶性、肿瘤大小、回声、钙化、微小乳头状癌的血管情况及包膜侵犯情况。采用单因素和多因素分析来研究超声特征与高容量淋巴结转移（转移淋巴结数量>5个）之间的关系。
共有152例患者发生高容量中央区淋巴结转移（6.4%，152/2363）。多因素logistic回归分析显示，术前超声特征中的微小钙化（OR = 3.33，p = 0.022）、较大肿瘤大小（>7mm）（OR = 2.802，p < 0.001）和包膜侵犯（OR = 2.141，p = 0.006）是PTMC中央区高容量淋巴结转移的独立危险因素。
甲状腺原发性微小乳头状癌的超声特征与高容量中央区淋巴结转移相关。
