Takada T, Yamamoto K, Fujioka S, Tamaki T, Fukui K, Abe Y
Jpn J Pharmacol. 1985 Jun;38(2):227-30. doi: 10.1254/jjp.38.227.
The effects of an orally active inhibitor of angiotensin-converting enzyme (SA-446) on systemic arterial pressure, renal function and renin release were examined in anesthetized dogs. Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. The smaller dose of SA-446 (0.02 mg/min) did not affect the blood pressure, but it increased the urine flow. However, the same dose of SA-446 in combination with probenecid caused a significant fall in blood pressure. The potentiation of SA-446 with probenecid may be explained by the elevation in plasma SA-446 concentration via the inhibition of its tubular secretion by probenecid.
在麻醉犬中研究了口服活性血管紧张素转换酶抑制剂（SA - 446）对全身动脉压、肾功能和肾素释放的影响。肾内输注较大剂量的SA - 446（0.1毫克/分钟）导致肾血流量、尿流量和肾素释放增加，并使血压下降。较小剂量的SA - 446（0.02毫克/分钟）不影响血压，但增加了尿流量。然而，相同剂量的SA - 446与丙磺舒联合使用会导致血压显著下降。丙磺舒对SA - 446的增效作用可能是由于丙磺舒抑制其肾小管分泌，使血浆SA - 446浓度升高所致。
