特应性皮炎患者血清及慢性皮肤损害中的视黄醇水平
Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis.
作者信息
Biswas Rabindranath, Chakraborti Goutam, Mukherjee Kheya, Bhattacharjee Debojyoti, Mallick Sabyasachi, Biswas Tanmoy
机构信息
Department of Dermatology, Malda Medical College and Hospital, Malda, West Bengal, India.
Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India.
出版信息
Indian J Dermatol. 2018 May-Jun;63(3):251-254. doi: 10.4103/ijd.IJD_763_16.
BACKGROUND
Atopic dermatitis (AD) is a common childhood dermatosis and a distressing cause of morbidity. The pathogenesis of AD is known to be associated with disorders of immune response and defect in antioxidant defense, genetic predisposition, environmental triggers, psychosomatic factors, and other mechanisms. Retinol has immunomodulatory and antioxidant effects, thus may have a protective role in AD.
OBJECTIVE
The objective of this study was to evaluate the correlation of retinol levels in skin lesions and serum, with AD.
MATERIALS AND METHODS
The study was a hospital-based, case-control study. Punch biopsy from the skin and venous blood of 86 participants (including 43 cases and 43 controls) were assayed for retinol levels by a reversed-phase high-performance liquid chromatography method. Analysis of data was performed using appropriate statistical methods.
RESULTS
Skin and serum retinol levels were highly significantly decreased in patients in respect to that of controls.
CONCLUSION
Retinol levels were decreased in AD. Retinol estimation may be used as a promising parameter for the elaboration of treatment strategy and monitoring.
背景
特应性皮炎（AD）是一种常见的儿童皮肤病，也是令人苦恼的发病原因。已知AD的发病机制与免疫反应紊乱、抗氧化防御缺陷、遗传易感性、环境触发因素、身心因素及其他机制有关。视黄醇具有免疫调节和抗氧化作用，因此可能在AD中发挥保护作用。
目的
本研究的目的是评估皮肤病变和血清中视黄醇水平与AD的相关性。
材料与方法
本研究是一项基于医院的病例对照研究。采用反相高效液相色谱法对86名参与者（包括43例病例和43例对照）的皮肤打孔活检组织和静脉血进行视黄醇水平检测。使用适当的统计方法进行数据分析。
结果
与对照组相比，患者的皮肤和血清视黄醇水平显著降低。
结论
AD患者的视黄醇水平降低。视黄醇测定可能作为制定治疗策略和监测的一个有前景的参数。
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