• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis.特应性皮炎患者血清及慢性皮肤损害中的视黄醇水平
Indian J Dermatol. 2018 May-Jun;63(3):251-254. doi: 10.4103/ijd.IJD_763_16.
2
Vitamin A in skin and serum--studies of acne vulgaris, atopic dermatitis, ichthyosis vulgaris and lichen planus.皮肤和血清中的维生素A——寻常痤疮、特应性皮炎、寻常鱼鳞病和扁平苔藓的研究
Br J Dermatol. 1985 Oct;113(4):405-13. doi: 10.1111/j.1365-2133.1985.tb02354.x.
3
Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis.抗氧化剂和维生素 D 水平与特应性皮炎患儿炎症的关系。
Int J Dermatol. 2019 Sep;58(9):1056-1061. doi: 10.1111/ijd.14438. Epub 2019 Apr 9.
4
A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis.金黄色葡萄球菌、白细胞介素-18、神经生长因子和轴突导向分子 Sema3A 在特应性皮炎发病机制和治疗中的作用。
Allergy Asthma Immunol Res. 2010 Oct;2(4):235-46. doi: 10.4168/aair.2010.2.4.235. Epub 2010 May 12.
5
Anti-atopic effect of Viola yedoensis ethanol extract against 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction.鸢尾叶乙醇提取物对 2,4-二硝基氯苯诱导的特应性皮炎样皮肤功能障碍的抗特应性作用。
J Ethnopharmacol. 2021 Nov 15;280:114474. doi: 10.1016/j.jep.2021.114474. Epub 2021 Jul 28.
6
Epigallocatechin gallate/L-ascorbic acid-loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis.负载表没食子儿茶素没食子酸酯/L-抗坏血酸的聚γ-谷氨酸微针，具有抗氧化、抗炎和免疫调节作用，用于治疗特应性皮炎。
Acta Biomater. 2021 Aug;130:223-233. doi: 10.1016/j.actbio.2021.05.032. Epub 2021 Jun 1.
7
Evaluation of Oxidant-Antioxidant Balance in Children with Atopic Dermatitis: A Case-Control Study.特应性皮炎患儿氧化应激-抗氧化平衡的评估：一项病例对照研究。
Am J Clin Dermatol. 2016 Oct;17(5):527-537. doi: 10.1007/s40257-016-0210-8.
8
Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic dermatitis in adults.胆红素氧化来源于氧化应激，与成人特应性皮炎的疾病严重程度相关。
Clin Exp Dermatol. 2019 Mar;44(2):153-160. doi: 10.1111/ced.13674. Epub 2018 Jun 4.
9
Serum IL-21 levels are elevated in atopic dermatitis patients with acute skin lesions.急性皮肤病变的特应性皮炎患者血清白细胞介素-21水平升高。
Allergol Int. 2017 Jul;66(3):440-444. doi: 10.1016/j.alit.2016.10.010. Epub 2016 Nov 22.
10
Effects of mineral complex material treatment on 2,4- dinitrochlorobenzene-induced atopic dermatitis like-skin lesions in mice model.矿物复合物处理对 2,4-二硝基氯苯诱导的小鼠模型特应性皮炎样皮肤损伤的影响。
BMC Complement Med Ther. 2021 Mar 3;21(1):82. doi: 10.1186/s12906-021-03259-5.

引用本文的文献

1
The Impact of Immune Cells, Metabolites, Inflammatory Factors, and Circulating Proteins on Atopic Dermatitis: Insights from a Mendelian Randomization Study.免疫细胞、代谢产物、炎症因子和循环蛋白对特应性皮炎的影响：孟德尔随机化研究的见解
Clin Cosmet Investig Dermatol. 2024 Dec 21;17:2999-3011. doi: 10.2147/CCID.S495217. eCollection 2024.
2
Malnutrition and Allergies: Tipping the Immune Balance towards Health.营养不良与过敏：使免疫平衡向健康倾斜
J Clin Med. 2024 Aug 11;13(16):4713. doi: 10.3390/jcm13164713.
3
Lack of iron, zinc, and vitamins as a contributor to the etiology of atopic diseases.铁、锌和维生素缺乏作为特应性疾病病因的一个因素。
Front Nutr. 2023 Jan 9;9:1032481. doi: 10.3389/fnut.2022.1032481. eCollection 2022.
4
Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients.特应性皮炎患者血浆中类胡萝卜素和视黄醇浓度降低，番茄红素异构体比例改变。
Nutrients. 2018 Oct 1;10(10):1390. doi: 10.3390/nu10101390.

本文引用的文献

1
Atopic Dermatitis: A Cross-Sectional (Descriptive) Study of 100 Cases.特应性皮炎：100例横断面（描述性）研究。
Indian J Dermatol. 2015 Sep-Oct;60(5):519. doi: 10.4103/0019-5154.164412.
2
Epidemiology and clinical features of atopic dermatitis in India.印度特应性皮炎的流行病学及临床特征
Indian J Dermatol. 2011 Sep-Oct;56(5):471-5. doi: 10.4103/0019-5154.87112.
3
Decreased retinoid concentration and retinoid signalling pathways in human atopic dermatitis.人特应性皮炎中视黄醇浓度降低和视黄醇信号通路。
Exp Dermatol. 2011 Apr;20(4):326-30. doi: 10.1111/j.1600-0625.2010.01225.x.
4
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.巨噬细胞的可塑性及其与淋巴细胞亚群的相互作用：以癌症为例。
Nat Immunol. 2010 Oct;11(10):889-96. doi: 10.1038/ni.1937. Epub 2010 Sep 20.
5
Alternative activation of macrophages: mechanism and functions.巨噬细胞的替代激活：机制与功能。
Immunity. 2010 May 28;32(5):593-604. doi: 10.1016/j.immuni.2010.05.007.
6
Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children.抗氧化营养素摄入与婴幼儿特应性皮炎风险相关的生物标志物。
Eur J Clin Nutr. 2010 Mar;64(3):245-52. doi: 10.1038/ejcn.2009.148. Epub 2010 Jan 27.
7
Retinol concentrations after birth are inversely associated with atopic manifestations in children and young adults.出生后的视黄醇浓度与儿童和年轻人的特应性表现呈负相关。
Clin Exp Allergy. 2007 Jan;37(1):54-61. doi: 10.1111/j.1365-2222.2006.02630.x.
8
Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.成年小鼠角质形成细胞中维甲酸X受体的缺失会引发由胸腺基质淋巴细胞生成素触发的特应性皮炎。
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14795-800. doi: 10.1073/pnas.0507385102. Epub 2005 Sep 30.
9
Oxidative stress in allergic and inflammatory skin diseases.过敏性和炎性皮肤病中的氧化应激
Curr Drug Targets Inflamm Allergy. 2005 Aug;4(4):517-9. doi: 10.2174/1568010054526386.
10
The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey.代谢综合征与抗氧化剂浓度：第三次全国健康与营养检查调查结果
Diabetes. 2003 Sep;52(9):2346-52. doi: 10.2337/diabetes.52.9.2346.

特应性皮炎患者血清及慢性皮肤损害中的视黄醇水平

Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis.

作者信息

Biswas Rabindranath, Chakraborti Goutam, Mukherjee Kheya, Bhattacharjee Debojyoti, Mallick Sabyasachi, Biswas Tanmoy

机构信息

Department of Dermatology, Malda Medical College and Hospital, Malda, West Bengal, India.

Department of Biochemistry, Murshidabad Medical College and Hospital, Berhampore, West Bengal, India.

出版信息

Indian J Dermatol. 2018 May-Jun;63(3):251-254. doi: 10.4103/ijd.IJD_763_16.

DOI:10.4103/ijd.IJD_763_16
PMID:29937563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5996635/
Abstract

BACKGROUND

Atopic dermatitis (AD) is a common childhood dermatosis and a distressing cause of morbidity. The pathogenesis of AD is known to be associated with disorders of immune response and defect in antioxidant defense, genetic predisposition, environmental triggers, psychosomatic factors, and other mechanisms. Retinol has immunomodulatory and antioxidant effects, thus may have a protective role in AD.

OBJECTIVE

The objective of this study was to evaluate the correlation of retinol levels in skin lesions and serum, with AD.

MATERIALS AND METHODS

The study was a hospital-based, case-control study. Punch biopsy from the skin and venous blood of 86 participants (including 43 cases and 43 controls) were assayed for retinol levels by a reversed-phase high-performance liquid chromatography method. Analysis of data was performed using appropriate statistical methods.

RESULTS

Skin and serum retinol levels were highly significantly decreased in patients in respect to that of controls.

CONCLUSION

Retinol levels were decreased in AD. Retinol estimation may be used as a promising parameter for the elaboration of treatment strategy and monitoring.

摘要

背景

特应性皮炎（AD）是一种常见的儿童皮肤病，也是令人苦恼的发病原因。已知AD的发病机制与免疫反应紊乱、抗氧化防御缺陷、遗传易感性、环境触发因素、身心因素及其他机制有关。视黄醇具有免疫调节和抗氧化作用，因此可能在AD中发挥保护作用。

目的

本研究的目的是评估皮肤病变和血清中视黄醇水平与AD的相关性。

材料与方法

本研究是一项基于医院的病例对照研究。采用反相高效液相色谱法对86名参与者（包括43例病例和43例对照）的皮肤打孔活检组织和静脉血进行视黄醇水平检测。使用适当的统计方法进行数据分析。

结果

与对照组相比，患者的皮肤和血清视黄醇水平显著降低。

结论

AD患者的视黄醇水平降低。视黄醇测定可能作为制定治疗策略和监测的一个有前景的参数。