Rollman O, Vahlquist A
Br J Dermatol. 1985 Oct;113(4):405-13. doi: 10.1111/j.1365-2133.1985.tb02354.x.
The concentrations of vitamin A and total carotenoids were measured in serum and skin of 61 patients with acne vulgaris, atopic dermatitis, ichthyosis vulgaris or lichen planus, and compared with those in 37 healthy subjects. The mean serum concentrations of retinol and retinol-binding protein were significantly decreased in patients with acne (P less than 0.01) and slightly increased in those with ichthyosis (P less than 0.05), but were otherwise normal. Serum carotenoid levels did not differ between patients and controls. Superficial shave biopsies from both involved and uninvolved skin were examined for the presence of retinol (vitamin A1), dehydroretinol (vitamin A2) and total carotenoids. The mean retinol concentration was increased in lichen planus lesions (P less than 0.05) and decreased in both acne skin (involved and uninvolved) and in lesions of atopic dermatitis (P less than 0.05). The mean dehydroretinol concentration was markedly increased in lesions of atopic dermatitis and lichen planus (P less than 0.01). No consistent abnormalities were found in skin of patients with ichthyosis vulgaris. The mean carotenoid concentration in the patients' skin did not differ significantly from that in the controls. The reduced retinol level in the skin of acne patients is probably explained by diminished supply of vitamin A from the blood. The abnormal ratio of retinol to dehydroretinol in lesions of lichen planus and atopic dermatitis is possibly due to changes in cutaneous vitamin A metabolism associated with epidermal hyperproliferation and inflammation.
对61例寻常痤疮、特应性皮炎、寻常鱼鳞病或扁平苔藓患者的血清和皮肤中的维生素A及总类胡萝卜素浓度进行了测定，并与37名健康受试者的相应浓度进行了比较。寻常痤疮患者血清视黄醇和视黄醇结合蛋白的平均浓度显著降低（P<0.01），鱼鳞病患者则略有升高（P<0.05），其他情况均正常。患者与对照组之间血清类胡萝卜素水平无差异。对受累皮肤和未受累皮肤进行浅表刮除活检，检测视黄醇（维生素A1）、脱氢视黄醇（维生素A2）和总类胡萝卜素的存在情况。扁平苔藓皮损中视黄醇平均浓度升高（P<0.05），寻常痤疮皮肤（受累和未受累）及特应性皮炎皮损中视黄醇平均浓度降低（P<0.05）。特应性皮炎和扁平苔藓皮损中脱氢视黄醇平均浓度显著升高（P<0.01）。寻常鱼鳞病患者皮肤未发现一致的异常情况。患者皮肤中类胡萝卜素的平均浓度与对照组相比无显著差异。寻常痤疮患者皮肤中视黄醇水平降低可能是由于血液中维生素A供应减少所致。扁平苔藓和特应性皮炎皮损中视黄醇与脱氢视黄醇的异常比例可能是由于与表皮过度增殖和炎症相关的皮肤维生素A代谢变化所致。
