Oral dysbacteriosis in type 2 diabetes and its role in the progression to cardiovascular disease.

BACKGROUND

Salivary changes and proliferation of specific bacterial communities are known to result in oral disease which may adversely impact on systemic conditions like diabetes and cardiovascular diseases.

OBJECTIVES

This study reports on the changes in oral ecology of healthy and diseased adults and the possible role in disease causation.

METHODS

The study comprised 150 participants divided into control (healthy), diabetic and cardiac groups. After dental examination for (Decayed Missing Filled Teeth (DMFT) and Oral Rating Index (ORI), stimulated saliva was sampled to determine flow rate and buffering capacity. Salivary microbial load of and were subsequently quantified.

RESULTS

DMFT, ORI, buffering capacity and flow rate were inferior for both diabetic and cardiac patients, who had higher bacterial counts (p<0.05). Long standing diabetics harboured a higher load of . The microbial load of in cardiac patients was double that of diabetics.

CONCLUSION

Disruption in the salivary environment and changes in microbial ecology with increased load of cariogenic bacteria were found in diabetic and cardiac patients. This study brings forward new evidence of a markedly higher load of in cardiac patients which may underlie the progression of diabetes to cardiovascular disease in this population.