自动氧化促进甘氨酸衍生物的 sp³ C-H 芳基化反应。
Auto-oxidation promoted sp C-H arylation of glycine derivatives.
机构信息
College of Chemistry and Chemical Engineering, Northwest Normal University Lanzhou, Gansu 730070, China.
出版信息
Org Biomol Chem. 2018 Jul 11;16(27):4985-4989. doi: 10.1039/c8ob01068d.
PMID:29938281
Abstract
An auto-oxidation promoted sp3 C-H arylation reaction between N-aryl glycine derivatives and electron-rich arenes, leading to the formation of N-aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.
摘要
一种自动氧化促进的 N-芳基甘氨酸衍生物和富电子芳环之间的 sp3 C-H 芳基化反应，生成 N-芳基 α-芳基 α-氨基酸衍生物，被描述。这种原子经济性和环境友好的反应在温和的反应条件下顺利进行，只需要 Brønsted 酸和氧气（气球）。提出了一种合理的自由基参与机制。
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