铈催化可见光诱导甘氨酸衍生物的C(sp)-H芳基化反应
Visible-light induced C(sp)-H arylation of glycine derivatives by cerium catalysis.
作者信息
Wang Shutao, Ye Yanjie, Shen Hailong, Liu Jiyu, Liu Zhao, Jiang Zhigen, Lei Junqiang, Zhang Yuan
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, P. R. China.
First Hospital of Lanzhou University, Lanzhou 730000, P. R. China.
出版信息
Org Biomol Chem. 2023 Oct 25;21(41):8364-8371. doi: 10.1039/d3ob01458d.
A Ce(III)-catalyzed, visible-light induced aerobic oxidative dehydrogenative coupling reaction between glycine derivatives and electron-rich arenes is disclosed. The protocol proceeds efficiently under mild conditions, providing an efficient method for the rapid synthesis of α-arylglycine derivatives without the need for an external photosensitizer and additional oxidant. Moreover, this protocol could be performed on a 5 mmol scale, without obvious reduction of the efficiency.
公开了一种铈（III）催化、可见光诱导的甘氨酸衍生物与富电子芳烃之间的需氧氧化脱氢偶联反应。该方法在温和条件下高效进行，为快速合成α-芳基甘氨酸衍生物提供了一种有效方法，无需外部光敏剂和额外的氧化剂。此外，该方法可以在5 mmol规模上进行，而效率没有明显降低。
Zotero 插件