Boyes Natasha G, Stickland Michael K, Fusnik Stephanie, Hogeweide Elizabeth, Fries Josie T J, Haykowsky Mark J, Baril Chantelle L, Runalls Shonah, Kakadekar Ashok, Pharis Scott, Pockett Charissa, Bradley Timothy J, Wright Kristi D, Erlandson Marta, Tomczak Corey R
College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Congenit Heart Dis. 2018 Jul;13(4):578-583. doi: 10.1111/chd.12614. Epub 2018 Jun 25.
Children with congenital heart disease are at risk for developing increased arterial stiffness and this may be modulated by physical activity.
To compare arterial stiffness in high- and low-physically active children with congenital heart disease and healthy age- and sex-matched controls.
Seventeen children with congenital heart disease (12 ± 2 years; females = 9), grouped by low- and high-physical activity levels from accelerometry step count values, and 20 matched controls (11 ± 3 years; females = 9) were studied.
Carotid-radial pulse wave velocity was assessed with applanation tonometry to determine arterial stiffness. Body composition and 6-min walk test measures were performed. Data were analyzed using analysis of variance and multiple regression. Significance was P < .05.
Arterial stiffness was increased in low-physically active children with congenital heart disease (9.79 ± 0.97 m/s) compared to high-physically active children with congenital heart disease (7.88 ± 0.71 m/s; P = .002) and healthy-matched controls (8.67 ± 1.28 m/s; P = .015). There were no differences in body composition measures between groups (all P > .05), but 6-min walk test distance was less in both congenital heart disease groups (high-physically active: 514 ± 40 m; low-physically active: 539 ± 49 m) versus controls (605 ± 79 m; all P < .05). Average daily step count significantly predicted arterial stiffness in children with congenital heart disease (R = 0.358) with a negative correlation (R = -0.599, P = .011), while % fat mass (P = .519) and % lean mass (P = .290) did not predict arterial stiffness.
Low-physically active children with congenital heart disease have increased arterial stiffness compared to high-physically active children with congenital heart disease and healthy-matched controls. Regular physical activity in children with congenital heart disease may modulate arterial stiffness.
先天性心脏病患儿有动脉僵硬度增加的风险，而这可能会受到体育活动的调节。
比较先天性心脏病患儿中高体力活动组和低体力活动组与年龄及性别匹配的健康对照组的动脉僵硬度。
对17名先天性心脏病患儿（12±2岁；女性9名）进行研究，根据加速度计步数计数值将其分为低体力活动组和高体力活动组，同时研究20名匹配的对照组（11±3岁；女性9名）。
采用压平式眼压计评估颈-桡脉搏波速度以确定动脉僵硬度。进行身体成分和6分钟步行试验测量。数据采用方差分析和多元回归进行分析。显著性水平为P<0.05。
与先天性心脏病高体力活动患儿（7.88±0.71米/秒；P=0.002）和健康匹配对照组（8.67±1.28米/秒；P=0.015）相比，先天性心脏病低体力活动患儿的动脉僵硬度增加（9.79±0.97米/秒）。各组间身体成分测量无差异（所有P>0.05），但先天性心脏病两组（高体力活动组：514±40米；低体力活动组：539±49米）的6分钟步行试验距离均短于对照组（605±79米；所有P<0.05）。平均每日步数显著预测先天性心脏病患儿的动脉僵硬度（R=0.358），呈负相关（R=-0.599，P=0.011），而体脂百分比（P=0.519）和瘦体重百分比（P=0.290）不能预测动脉僵硬度。
与先天性心脏病高体力活动患儿和健康匹配对照组相比，先天性心脏病低体力活动患儿的动脉僵硬度增加。先天性心脏病患儿进行规律体育活动可能会调节动脉僵硬度。
