SEER 研究比较了 cT1A 期肾细胞癌的消融与部分肾切除术。

SEER study of ablation versus partial nephrectomy in cT1A renal cell carcinoma.

机构信息

Division of Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine in St Louis, St Louis, MO, USA.

Siteman Cancer Center at Washington University in St Louis, St Louis, MO, USA.

出版信息

Future Oncol. 2018 Jul;14(17):1711-1719. doi: 10.2217/fon-2017-0678. Epub 2018 Jun 25.

DOI:10.2217/fon-2017-0678

PMID:29939095

Abstract

AIM

Compare ablation versus partial nephrectomy (PN) in T1A renal cell carcinoma (RCC) treatment, using the SEER database.

METHODS

Patients with diagnosed T1A RCC from 2004 to 2013 were identified. Propensity matching paired subjects with similar background variables. Kaplan-Meier and Cox proportional hazards regression were performed before and after matching.

RESULTS

Cohort included 4592 patients (809 ablation, 3783 PN). PN compared with ablation group had significantly increased overall survival (OS; 93.6% vs 81.9% 5-year survival; p < 0.0001) and cancer-specific survival (CSS; p < 0.0001). After matching (1222 pairs), PN group had significantly increased OS (91.0% vs 86.3% 5-year survival; p = 0.0457) but similar CSS (p = 0.4023).

CONCLUSION

Ablation offers similar CSS but lower OS as PN for T1A RCC in this SEER database.

摘要

目的

利用 SEER 数据库比较 T1A 肾细胞癌（RCC）治疗中消融与部分肾切除术（PN）的疗效。

方法

从 2004 年至 2013 年，确定了诊断为 T1A RCC 的患者。对具有相似背景变量的患者进行倾向评分匹配配对。在匹配前后进行 Kaplan-Meier 和 Cox 比例风险回归分析。

结果

队列纳入 4592 例患者（809 例消融，3783 例 PN）。与消融组相比，PN 组的总生存率（OS；5 年生存率 93.6% vs 81.9%；p<0.0001）和癌症特异性生存率（CSS；p<0.0001）显著提高。在匹配后（1222 对），PN 组的 OS 显著提高（91.0% vs 86.3%，5 年生存率；p=0.0457），但 CSS 相似（p=0.4023）。