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如实告知抗生素:基层医疗中为儿童开处方的益处、危害和道德责任。

Telling the truth about antibiotics: benefits, harms and moral duty in prescribing for children in primary care.

机构信息

Child Health Unit, Department of Primary Care and Public Health, School of Public Health, Imperial College London, Reynolds Building, St Dunstan's Road, London, UK.

Nuffield Department of Primary Health Sciences, Medical Sciences Division, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, UK.

出版信息

J Antimicrob Chemother. 2018 Sep 1;73(9):2298-2304. doi: 10.1093/jac/dky223.

DOI:10.1093/jac/dky223
PMID:29939282
Abstract

Antimicrobial resistance represents a growing threat to global health, yet antibiotics are frequently prescribed in primary care for acute childhood illness, where there is evidence of very limited clinical effectiveness. Moral philosophy supports the need for doctors to consider wider society, including future patients, when treating present individuals, and it is clearly wrong to waste antibiotics in situations where they are largely clinically ineffective at the expense of future generations. Doctors should feel confident in applying principles of antibiotic stewardship when treating children in primary care, but they must explain these to parents. Provision of accurate, accessible information about the benefits and harms of antibiotics is key to an ethical approach to antimicrobial stewardship and to supporting shared decision making. Openness and honesty about drivers for antibiotic requests and prescribing may further allow parents to have their concerns heard and help clinicians to develop with them an understanding of shared goals.

摘要

抗生素耐药性对全球健康构成日益严重的威胁,但在初级保健中,抗生素经常被用于治疗急性儿童疾病,而这些疾病的临床疗效非常有限。道德哲学支持医生在治疗现有个体时考虑更广泛的社会,包括未来的患者,在抗生素在很大程度上临床无效的情况下浪费抗生素,这显然是错误的,这会损害到后代的利益。当在初级保健中治疗儿童时,医生应该有信心应用抗生素管理原则,但他们必须向家长解释这些原则。提供有关抗生素益处和危害的准确、易获取的信息是实施抗菌药物管理伦理方法和支持共同决策的关键。坦诚和诚实地说明抗生素使用的驱动因素和开具处方的原因,可能会进一步让家长的担忧得到倾听,并帮助临床医生与他们共同理解共同的目标。

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引用本文的文献

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BMC Public Health. 2024 Oct 14;24(1):2820. doi: 10.1186/s12889-024-20248-8.
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If antibiotics aren't always the answer-what is?如果抗生素并非总是答案——那什么是呢?
Pediatr Res. 2025 Feb;97(2):469-470. doi: 10.1038/s41390-024-03632-3. Epub 2024 Oct 9.
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Shifting the antibiotic rhetoric in children from 'just in case' to 'disclose the risk': Has the time come?
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J Assoc Med Microbiol Infect Dis Can. 2024 Mar 29;9(1):6-10. doi: 10.3138/jammi-2023-12-08. eCollection 2024 Mar.