Biotechnology Research Center , Toyama Prefectural University , Imizu , Toyama 939-0398 , Japan.
Department of Biology, Faculty of Science , Burapha University , Chonburi 20131 , Thailand.
J Nat Prod. 2018 Jul 27;81(7):1561-1569. doi: 10.1021/acs.jnatprod.8b00071. Epub 2018 Jun 25.
Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus Sphaerimonospora. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. In silico analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20-40 μM without showing cytotoxicity.
两种新的呋喃酮类聚酮化合物，linfuranones B 和 C，从一株植物相关的游动放线菌属 Sphaerimonospora 中分离得到。它们的结构通过 NMR 和 MS 光谱分析确定，绝对构型通过各向异性方法和化学降解方法建立。生物合成基因的计算机分析表明，linfuranone B 是通过聚酮链的氧化裂解从 linfuranone C 生成的。linfuranones B 和 C 在没有显示细胞毒性的情况下，在 20-40 μM 浓度下诱导前体脂肪细胞分化为成熟脂肪细胞。
