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18F-FDG PET/CT 检测到的局灶性到弥漫性甲状腺摄取进展:恶性转移疾病还是良性甲状腺炎?

Progression of Focal to Diffuse Thyroid Uptake Detected by 18F-FDG PET/CT: Malignant Metastatic Disease or Benign Thyroiditis?

机构信息

Departments of Oncology and.

出版信息

Clin Nucl Med. 2018 Sep;43(9):e310-e311. doi: 10.1097/RLU.0000000000002168.

DOI:10.1097/RLU.0000000000002168
PMID:29939952
Abstract

A 49-year-old man was referred to our department for an assessment of a cerebral metastasis of unknown primary with F-FDG PET/CT. This imaging led to detection of a suspected pulmonary primary carcinoma, as well as an incidental left focal thyroid uptake. An ultrasonography, performed a month later, revealed a thyroiditis aspect. An anti-PD1 immunotherapy was also proposed 2 months later after confirmation of a lung adenocarcinoma. A second baseline FDG PET/CT surprisingly showed a diffuse thyroid uptake. A fine-needle aspiration biopsy of thyroid parenchyma finally revealed a diffuse involvement from lung adenocarcinoma (ie, primary lung metastasis to the thyroid gland).

摘要

一位 49 岁男性因 F-FDG PET/CT 检查发现不明原发灶的脑部转移而被转至我科评估。该影像学检查还发现疑似肺部原发性癌,以及偶然发现左侧甲状腺局灶性摄取。一个月后进行的超声检查显示为甲状腺炎表现。在确认肺腺癌后 2 个月,还提出了抗 PD1 免疫治疗。然而,第二次基线 FDG PET/CT 检查出人意料地显示甲状腺弥漫摄取。甲状腺实质的细针抽吸活检最终显示出由肺腺癌弥漫累及(即,肺部原发性转移至甲状腺)。

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