全胃切除术对血清和尿液中酸性蛋白水解酶原的影响。

Effect of total gastrectomy on acid proteolytic zymogens in serum and urine.

作者信息

Ishimori A, Sakurada H, Kawamura T, Hashimoto H, Yamagata S

出版信息

Tohoku J Exp Med. 1976 Jan;118(1):45-51. doi: 10.1620/tjem.118.45.

DOI:10.1620/tjem.118.45

Abstract

Proteolytic pH-activity curve and agar gel electrophoretic pattern of acid proteolytic zymogens in serum and urine were studied in totally gastrectomized patients. In serum, total gastrectomy was found to reduce proteolytic activity markedly, but no appreciable changes could be detected by electrophoretic analysis. In urine, however, in addition to the marked reduction of proteolytic activity, changes were found in electrophoretic pattern after total gastrectomy. Namely, fraction Pg 3 tended to persist, while Pg 5 disappeared along with the lapse of time after total gastrectomy. An unusual appearance of fraction Pg 7 in urine was also observed on the occasion of postoperative transient albuminuria. Their orgins and related clinical problems were discussed.

摘要

对全胃切除患者血清和尿液中酸性蛋白水解酶原的蛋白水解pH活性曲线及琼脂凝胶电泳图谱进行了研究。在血清中，发现全胃切除可显著降低蛋白水解活性，但电泳分析未检测到明显变化。然而，在尿液中，除蛋白水解活性显著降低外，全胃切除术后电泳图谱也发生了变化。即，Pg 3组分倾向于持续存在，而Pg 5组分在全胃切除术后随时间推移而消失。在术后短暂蛋白尿期间，还观察到尿液中出现了异常的Pg 7组分。对它们的来源及相关临床问题进行了讨论。