Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands; Department of Radiology, UMC Utrecht, The Netherlands.
Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands; Department of Radiology, UMC Utrecht, The Netherlands.
Neuroimage. 2018 Oct 1;179:337-347. doi: 10.1016/j.neuroimage.2018.06.062. Epub 2018 Jun 22.
The relevance of human primary motor cortex (M1) for motor actions has long been established. However, it is still unknown how motor actions are represented, and whether M1 contains an ordered somatotopy at the mesoscopic level. In the current study we show that a detailed within-limb somatotopy can be obtained in M1 during finger movements using Gaussian population Receptive Field (pRF) models. Similar organizations were also obtained for primary somatosensory cortex (S1), showing that individual finger representations are interconnected throughout sensorimotor cortex. The current study additionally estimates receptive field sizes of neuronal populations, showing differences between finger digit representations, between M1 and S1, and additionally between finger digit flexion and extension. Using the Gaussian pRF approach, the detailed somatotopic organization of M1 can be obtained including underlying characteristics, allowing for the in-depth investigation of cortical motor representation and sensorimotor integration.
人类初级运动皮层（M1）与运动动作的相关性早已确立。然而，运动动作是如何被表示的，以及 M1 是否在中观水平上包含有序的体感觉定位，目前仍不清楚。在目前的研究中，我们使用高斯总体感受野（pRF）模型表明，在手指运动过程中可以在 M1 中获得详细的肢体内部体感觉定位。在初级体感皮层（S1）中也获得了类似的组织，表明个体手指代表在感觉运动皮层中相互连接。本研究还估计了神经元群体的感受野大小，显示了手指数字表示之间、M1 和 S1 之间以及手指数字屈伸之间的差异。使用高斯 pRF 方法，可以获得包括潜在特征在内的 M1 的详细体感觉组织，从而可以深入研究皮质运动代表和感觉运动整合。
