帕金森病中的气质特征与执行功能

Temperament traits and executive functions in Parkinson's disease.

作者信息

Luca Antonina, Nicoletti Alessandra, Mostile Giovanni, Sciacca Giorgia, Dibilio Valeria, Cicero Calogero Edoardo, Raciti Loredana, Donzuso Giulia, Zappia Mario

机构信息

Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Via Santa Sofia 79, 95123, Catania, Italy.

出版信息

Neurosci Lett. 2018 Sep 25;684:25-28. doi: 10.1016/j.neulet.2018.06.040. Epub 2018 Jun 22.

DOI:10.1016/j.neulet.2018.06.040

PMID:29940327

Abstract

INTRODUCTION

Aim of the study was to evaluate the possible relationship between Temperament traits and executive dysfunction in patients with Parkinson's disease (PD).

METHODS

Patients affected by PD diagnosed according to the UK Parkinson's disease Society Brain Bank criteria were enrolled in the study. Patients with a Mini Mental State Examination <24 were excluded from the study. The Temperament and Character Inventory (TCI), a self-report questionnaire assessing the Harm Avoidance (HA), Novelty Seeking (NS) and Reward Dependence (RD) temperamental traits, has been performed. The executive functions were assessed with the Frontal Assessment Battery (FAB).

RESULTS

Fifty PD patients (28 men and 22 women; mean age 59.1 ± 10.1 years) were enrolled. High HA (mean score 73.3 ± 24.7) and a low NS score (24.2 ± 18.7) were recorded. Fifteen (30%) patients presented a pathological FAB score (≤13.5). Patients with a pathological FAB score presented an HA score significantly higher than patients with normal FAB score (respectively 84.9 ± 13.7 versus 69.8 ± 26.9; p = 0.045). At the univariate analysis an association between high HA score and pathological FAB score was found (OR 3.85, 95%CI 1.06-13.9; p-value 0.040).

CONCLUSION

Our study confirmed an association between executive disturbances and HA in PD patients, possibly related to a common impairment of the frontostriatal circuits.

摘要

引言

本研究的目的是评估帕金森病（PD）患者的气质特征与执行功能障碍之间的可能关系。

方法

根据英国帕金森病协会脑库标准确诊的PD患者纳入本研究。简易精神状态检查表得分<24分的患者被排除在研究之外。采用气质性格量表（TCI）这一自我报告问卷来评估回避伤害（HA）、寻求新奇（NS）和奖赏依赖（RD）气质特征。使用额叶评估量表（FAB）评估执行功能。

结果

共纳入50例PD患者（28例男性和22例女性；平均年龄59.1±10.1岁）。记录到高HA得分（平均得分73.3±24.7）和低NS得分（24.2±18.7）。15例（30%）患者的FAB得分病理性（≤13.5）。FAB得分病理性的患者HA得分显著高于FAB得分正常的患者（分别为84.9±13.7对69.8±26.9；p=0.045）。单因素分析发现高HA得分与病理性FAB得分之间存在关联（比值比3.85，95%置信区间1.06-13.9；p值0.040）。