Department of Psychiatry, Medical Faculty of Masaryk University, University Hospital Brno and, Czech Republic; Applied Neurosciences Research Group, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic.
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
J Psychiatr Res. 2018 Sep;104:46-49. doi: 10.1016/j.jpsychires.2018.06.012. Epub 2018 Jun 15.
We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.
我们之前的研究表明，与中度抑郁发作的患者相比，重度抑郁发作的患者醛固酮浓度更高。本研究旨在验证这样一个假设，即循环醛固酮浓度反映了精神分裂症患者的临床状态。该样本包括 36 名住院患者（25 名男性，11 名女性），他们患有首发或长期精神分裂症。使用阳性和阴性症状量表（PANSS）评估精神病理学的严重程度。用于测量血清醛固酮的样本是在患者醒来后立即采集的。结果表明，首发组患者的血清醛固酮浓度明显低于长期组。重要的是，首发组患者中观察到的较低的醛固酮浓度与 PANSS 所有分量表所指示的更严重的临床症状有关。两组患者的血清皮质醇浓度无差异，而醛固酮/皮质醇比值与醛固酮浓度呈现相似的模式。本初步研究表明，精神分裂症患者的循环醛固酮可能反映了临床症状的严重程度，但与重度抑郁症患者的情况相反。
