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与外科病房相比,内分泌病房中甲状腺切除术后甲状旁腺功能减退所致低钙血症患者的筛查与管理

Screening and management of postoperative hypoparathyroidism-induced hypocalcemia in thyroidectomized patients in the endocrine ward compared with the surgical ward.

作者信息

Sauer Nina, Lautenbach Anne, Pohl Katharina, Schön Gerhard, Brose Hans-Peter, Schulze Zur Wiesch Clarissa Alexandra, Aberle Jens Carsten

机构信息

Department of Endocrinology and Diabetology, Martinistraße 52 Hamburg 20246, Germany.

出版信息

Ear Nose Throat J. 2018 Apr-May;97(4-5):E22-E26.

Abstract

Transient hypoparathyroid-associated hypocalcemia is a common side effect after thyroidectomy. Not only may it be life-threatening, but it also can distinctly affect length of hospital stay and treatment costs. Screening and treatment practices are suspected to differ between clinicians in endocrine and surgical wards. We therefore compared discipline-related differences in screening and treatment of hypocalcemia as well as the length of hospital stay of patients after thyroidectomy. Data from 170 patients treated with total thyroidectomy in the Department of Otolaryngology (n = 29), General Surgery (n = 49) and Endocrinology (n = 92) were analyzed, and measurements of postoperative calcium and parathyroid hormone, calcium at time of discharge, percentage of discharge with a calcium level <1.9 mmol/L (defined as severe hypocalcemia), treatment of hypocalcemia, and duration of hospitalization were compared between disciplines. Postoperative calcium levels were measured in 97.8% of patients in endocrine wards compared with 83.3% in surgical departments (p = 0.001), and discharge with a calcium level <1.9 mmol/L was statistically more frequent in surgical vs. endocrine wards. Additional to calcium supplementation, active vitamin D was administered in 95% of patients treated in endocrine wards vs. 35% in surgical wards. Length of hospitalization was 8.12 (±6.62) days (endocrinology) to 10.55 (±9.39) days (surgical wards) (p = 0.05). Monitoring of calcium levels is an important indicator of the quality of postoperative care after thyroidectomy. To prevent postoperative hypocalcemia-induced complications and to reduce the length of hospital stay, an interdisciplinary approach for the management of hypocalcemia after thyroidectomy might be a promising model for future treatment concepts.

摘要

短暂性甲状旁腺功能减退相关的低钙血症是甲状腺切除术后常见的副作用。它不仅可能危及生命,还会显著影响住院时间和治疗费用。内分泌科和外科病房的临床医生在筛查和治疗方法上可能存在差异。因此,我们比较了甲状腺切除术后低钙血症筛查和治疗方面的学科差异以及患者的住院时间。分析了耳鼻咽喉科(n = 29)、普通外科(n = 49)和内分泌科(n = 92)接受全甲状腺切除术的170例患者的数据,并比较了各学科术后钙和甲状旁腺激素的测量值、出院时的血钙水平、血钙水平<1.9 mmol/L(定义为严重低钙血症)的出院患者百分比、低钙血症的治疗情况以及住院时间。内分泌病房97.8%的患者进行了术后血钙水平测量,而外科病房这一比例为83.3%(p = 0.001),外科病房出院时血钙水平<1.9 mmol/L的情况在统计学上比内分泌病房更常见。在内分泌病房接受治疗的患者中,95%除补充钙剂外还使用了活性维生素D,而外科病房这一比例为35%。住院时间为内分泌科8.12(±±6.62)天至外科病房10.55(±±9.39)天(p = 0.05)。血钙水平监测是甲状腺切除术后术后护理质量的重要指标。为预防术后低钙血症引起的并发症并缩短住院时间,甲状腺切除术后低钙血症的跨学科管理方法可能是未来治疗理念的一个有前景的模式。

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