The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
Neoplasma. 2018;65(4):572-578. doi: 10.4149/neo_2018_170814N530.
Deregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study identified that miR-129-5p suppresses proliferation and metastasis in breast cancer cells. Herein, we determined that CBX4 is a miR-129-5p target gene. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. These combined results suggest that CBX4 is an oncogene in breast cancer cells, and that it may provide a novel therapeutic strategy for breast cancer treatment.
miRNA 的失调与癌症的发生和发展密切相关。我们之前的研究表明，miR-129-5p 抑制乳腺癌细胞的增殖和转移。在此，我们确定 CBX4 是 miR-129-5p 的靶基因。CBX4 在乳腺癌组织中上调，而其过表达促进细胞增殖，其敲低则抑制乳腺癌细胞的增殖。此外，CBX4 介导 miR-129-5p 诱导的细胞增殖抑制，与 miR-129-5p 的表达呈负相关。这些综合结果表明，CBX4 是乳腺癌细胞中的癌基因，它可能为乳腺癌的治疗提供一种新的治疗策略。
