在中国非糖尿病患者中，循环全长血管生成素样蛋白 8 水平与冠状动脉疾病严重程度的相关性：一项病例对照研究。
Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case-control study.
机构信息
Key Laboratory of Remodeling-related Cardiovascular Diseases, Beijing An Zhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing An Zhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, 100029, China.
出版信息
Cardiovasc Diabetol. 2018 Jun 25;17(1):92. doi: 10.1186/s12933-018-0736-6.
BACKGROUND
Angiopoietin-like protein 8 (ANGPTL8), which is a novel hormone produced in liver and adipose tissue, is involved in regulating lipid metabolism. Patients with diabetes and coronary artery disease (CAD) have remarkably higher levels of ANGPTL8 than those with only diabetes. However, no studies have investigated the involvement of ANGPTL8 in CAD in Chinese non-diabetic individuals. Therefore, we investigated full-length circulating ANGPTL8 levels in patients with CAD and the association between ANGPT8 levels and severity of CAD in Chinese individuals without diabetes.
METHODS
We performed a case-control study in 149 Chinese non-diabetic subjects, including 80 patients with CAD and 69 controls. The Gensini stenosis scoring system was used to assess the severity of CAD. Circulating full-length ANGPTL8 levels were measured by an enzyme-linked immunosorbent assay kit. The associations between circulating full-length ANGPTL8 levels and CAD were determined by multivariate logistic regression analysis. The association between ANGPTL8 levels and Gensini scores was determined by multivariate linear regression analysis.
RESULTS
Circulating full-length ANGPTL8 levels were significantly higher in Chinese non-diabetic patients with CAD compared with controls (665.90 ± 243.49 vs 462.27 ± 151.85 pg/ml, P < 0.001). After adjusting for confounding factors, we found that circulating full-length ANGPTL8 levels were an independent risk factor for CAD (odds ratio = 2.002/100 pg ANGPTL8, 95% CI 1.430-2.803, P < 0.001) and circulating ANGPTL8 levels were positively associated with the Gensini score (β = 5.701/100 pg ANGPTL8, 95% CI 1.306-10.096, P = 0.012).
CONCLUSIONS
This study shows that the circulating ANGPTL8 levels are significantly increased in patients with CAD compared with controls in Chinese non-diabetic individuals. Circulating full-length ANGPTL8 levels are an independent risk factor for CAD and they are positively associated with the severity of CAD. Trial registration This study was registered in the Chinese Clinical Trial Registry (No. ChiCTR-COC-17010792).
背景
血管生成素样蛋白 8（ANGPTL8）是一种新型激素，主要在肝脏和脂肪组织中产生，参与调节脂质代谢。患有糖尿病和冠心病（CAD）的患者的 ANGPTL8 水平明显高于仅患有糖尿病的患者。然而，尚无研究调查 ANGPTL8 在非糖尿病中国个体 CAD 中的作用。因此，我们研究了 CAD 患者全长循环 ANGPTL8 水平以及 ANGPT8 水平与中国非糖尿病个体 CAD 严重程度之间的关系。
方法
我们在中国的 149 名非糖尿病患者中进行了病例对照研究，其中 80 名患者患有 CAD，69 名患者为对照组。使用 Gensini 狭窄评分系统评估 CAD 的严重程度。通过酶联免疫吸附试验试剂盒测量全长循环 ANGPTL8 水平。通过多元逻辑回归分析确定全长循环 ANGPTL8 水平与 CAD 之间的关联。通过多元线性回归分析确定 ANGPTL8 水平与 Gensini 评分之间的关联。
结果
与对照组相比，中国非糖尿病 CAD 患者的全长循环 ANGPTL8 水平明显升高（665.90 ± 243.49 vs 462.27 ± 151.85 pg/ml，P < 0.001）。在调整混杂因素后，我们发现全长循环 ANGPTL8 水平是 CAD 的独立危险因素（比值比= 2.002/100 pg ANGPTL8，95%置信区间 1.430-2.803，P < 0.001），全长循环 ANGPTL8 水平与 Gensini 评分呈正相关（β= 5.701/100 pg ANGPTL8，95%置信区间 1.306-10.096，P = 0.012）。
结论
这项研究表明，与对照组相比，中国非糖尿病 CAD 患者的全长循环 ANGPTL8 水平显著升高。全长循环 ANGPTL8 水平是 CAD 的独立危险因素，与 CAD 的严重程度呈正相关。
试验注册
本研究在中国临床试验注册中心（注册号 ChiCTR-COC-17010792）注册。
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