Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD, United States.
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD, United States.
Adv Cancer Res. 2018;139:85-120. doi: 10.1016/bs.acr.2018.04.003. Epub 2018 May 18.
This chapter reviews the use of dendronized systems as nanocarriers for the delivery of chemotherapeutic drugs. Dendronized systems include dendrimers prepared through convergent methods as well as other systems containing dendrons (e.g., polymers, nanoparticles, liposomes). The preparation of such systems is detailed, followed by the various conjugation techniques used for the transport of chemotherapeutic drugs and their specific delivery to tumor cells. In addition, the ability of dendronized systems to provide passive and active targeting to tumors is discussed. The efficacy of drug delivery using dendronized systems is also illustrated through specific examples of kinetic and biological studies. Finally, the newest trends in conjugation of the most common chemotherapeutics to dendronized systems are described. Overall, this chapter highlights dendronized systems as a way to improve the therapeutic efficiency of drugs for the treatment of cancer. All the recent developments in areas, such as biodegradable dendrimers, modifications to enhance biocompatibility, selectively cleavable drug conjugations, ligand-mediated targeting, and the potential for multifunctional properties, show promises for future advances in cancer therapy.
这一章回顾了树枝状系统作为化疗药物传递的纳米载体的应用。树枝状系统包括通过收敛方法制备的树枝状聚合物以及包含树枝状结构的其他系统（例如聚合物、纳米粒子、脂质体）。详细介绍了这些系统的制备方法，以及用于运输化疗药物及其特异性递送至肿瘤细胞的各种连接技术。此外，还讨论了树枝状系统提供被动和主动靶向肿瘤的能力。通过动力学和生物学研究的具体实例说明了使用树枝状系统进行药物传递的功效。最后，描述了将最常见的化疗药物与树枝状系统连接的最新趋势。总的来说，本章强调了树枝状系统作为提高癌症治疗药物治疗效果的一种方法。在可生物降解的树枝状聚合物、增强生物相容性的修饰、选择性可切割的药物连接、配体介导的靶向以及多功能特性的潜力等领域的最新进展，为癌症治疗的未来进展带来了希望。
