Church A C, Flexner J B, Flexner L B, Rainbow T C
Pharmacol Biochem Behav. 1985 Jul;23(1):27-31. doi: 10.1016/0091-3057(85)90125-x.
Using bitemporal injections of puromycin, we have reported observations interpreted to indicate that a systemic injection of (-)-propranolol (50 micrograms/kg) drastically suppressed the spread of an engram in mice from the hippocampalentorhinal area to widespread cerebral areas. The present experiments were made with a non-selective, irreversible beta-adrenergic receptor antagonist that fails to cross the blood-brain barrier in order to test the possibility that the propranolol-induced blockade of peripheral beta-receptors might contribute to its effect on engram spread. Prolonged blockade of peripheral receptors by the irreversible antagonist had no effect on engram spread, suggesting that propranolol's effect was centrally mediated.
通过双颞叶注射嘌呤霉素，我们报告了一些观察结果，这些结果被解释为表明全身注射（-）-普萘洛尔（50微克/千克）可显著抑制小鼠中记忆痕迹从海马旁嗅区扩散到广泛的脑区。本实验使用了一种非选择性、不可逆的β-肾上腺素能受体拮抗剂，该拮抗剂无法穿过血脑屏障，以测试普萘洛尔诱导的外周β受体阻断可能对其记忆痕迹扩散效应产生影响的可能性。不可逆拮抗剂对外周受体的长期阻断对记忆痕迹扩散没有影响，这表明普萘洛尔的作用是由中枢介导的。
