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重型β地中海贫血患儿的血清铁调素水平

Serum Hepcidin Levels in Children with Beta Thalassemia Major.

作者信息

Jagadishkumar K, Yerraguntla Naresh, Vaddambal Manjunath Gopalakrishna

机构信息

Department of Pediatrics, JSS Medical College, JSS University Mysore,Mysore, Karnataka, India.

Department of Pediatrics, JSS Medical College, JSS University Mysore, Mysore, Karnataka, India.

出版信息

Indian Pediatr. 2018 Oct 15;55(10):911-912. Epub 2018 Jun 13.


DOI:
PMID:29941702
Abstract

The mean (SD) serum hepcidin levels in 40 children with thalassemia [15.8 (2.9) ng/mL] were comparable to those seen in 40 healthy controls [15.1 (3.0) ng/mL (P=0.3)]. The hepcidin/ferritin ratio in thalassemic children was significantly lower (P<0.001) suggesting that hepcidin levels were not increased in proportion to the iron overload.

摘要

40名地中海贫血患儿的血清铁调素水平均值(标准差)为[15.8(2.9)ng/mL],与40名健康对照者[15.1(3.0)ng/mL(P=0.3)]相当。地中海贫血患儿的铁调素/铁蛋白比值显著更低(P<0.001),提示铁调素水平并未随铁过载成比例升高。

相似文献

[1]
Serum Hepcidin Levels in Children with Beta Thalassemia Major.

Indian Pediatr. 2018-10-15

[2]
Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major.

Indian J Pediatr. 2017-6-10

[3]
Correlation of hepcidin level with insulin resistance and endocrine glands function in major thalassemia.

Adv Clin Exp Med. 2015

[4]
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Egypt J Immunol. 2010

[5]
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[6]
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Hemoglobin. 2021-1

[7]
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[8]
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[9]
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Ann Hematol. 2019-12-13

[10]
Analysis of Glycosylation Profiles of Serum Glycoprotein from Iron Overload Thalassemia.

Clin Lab. 2018-7-1

引用本文的文献

[1]
Reduced hepcidin expression enhances iron overload in patients with HbE/β-thalassemia: Α comparative cross-sectional study.

Exp Ther Med. 2021-12

[2]
Iron Status in Newly Diagnosed -Thalassemia Major: High Rate of Iron Status due to Erythropoiesis Drive.

Biomed Res Int. 2021

[3]
Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital.

Biosci Rep. 2021-2-26

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