Cheung Chi Yuen, Lau Wing Hung, Cheuk Wah
1 Queen Elizabeth Hospital, Hong Kong, China SAR.
Int J Surg Pathol. 2019 Feb;27(1):94-97. doi: 10.1177/1066896918784184. Epub 2018 Jun 26.
A 56-year-old man, who received deceased kidney transplant 20 years ago, presented with an enlarged submandibular lymph node. Histologic examination revealed nodal marginal zone lymphoma in which the neoplastic lymphoid cells showed diffuse positivity for Epstein-Barr virus early RNA by in situ hybridization. Systemic lymphoma workup showed stage I disease. The tumor was managed as a posttransplant lymphoproliferative disorder and the immunosuppression was modified. There was no evidence of lymphoma at follow-up 6 years after excision alone. This case supports the inclusion of Epstein-Barr virus-positive nodal marginal zone lymphoma as a form of monomorphic B-cell lymphoproliferative disorder, in line with the status of its extranodal mucosa-associated lymphoid tissue lymphoma counterpart.
一名56岁男性，20年前接受了尸体肾移植，现出现下颌下淋巴结肿大。组织学检查显示为淋巴结边缘区淋巴瘤，其中肿瘤性淋巴细胞通过原位杂交显示对爱泼斯坦-巴尔病毒早期RNA呈弥漫性阳性。全身淋巴瘤检查显示为I期疾病。该肿瘤被作为移植后淋巴增殖性疾病进行处理，并调整了免疫抑制。单纯切除术后6年的随访中未发现淋巴瘤证据。该病例支持将爱泼斯坦-巴尔病毒阳性淋巴结边缘区淋巴瘤纳入单形性B细胞淋巴增殖性疾病的范畴，这与其结外黏膜相关淋巴组织淋巴瘤对应物的情况一致。
