Zhu H, Lei H, Wang Q, Fu J, Song Y, Shen L, Huang W
Clin Exp Obstet Gynecol. 2016;43(6):826-829.
To define the utility of serum carcinogenic antigen (CA)-125 and CA 19-9 combining pain score in the prediction of pelvic endometriosis in infertile women.
Serum CA-125 and CA 19-9 were measured using immunoradiologic methods during the follicular phase preceding laparoscopy for infertility. Values obtained were correlated with the occurrence and severity of endometriosis. Receiver operating characteristic (ROC) curve was applied to assess the utility of serum CA-125, CA 19-9, and pain score in preoperative preparation. Cut-off value of CA-125 and CA 19-9 was defined.
The study enrolled 294 infertile women receiving laparoscopy between July 2010 and September 2011. Ninety-four patients were diagnosed with endometriosis and 200 patients without. Preoperative serum CA-125 and CA 19-9 levels were significantly different between the two groups. ROC curve analyses of serum CA-125 and CA 19-9 set a cut-off value of 18.25 IU/ml and 13.15 IU/ml, producing a sensitivity of 64.8% and 84.8%, a specificity of 81.9% and 51.6%, a positive predictive value (PPV) of 63.6% and 46.1%, and a negative predictive value (NPV) of 81.0% and 87.4%, respectively. Combined-analyses of CA-125 and CA 19-9 produced a sensitivity of 72.4%, a specificity of 81.9%, a PPV of 62.3%, and a NPV of 81.8%. Combined-analyses of serum CA-125, CA 19-9 and pain score produced a sensitivity of 71.0% and a specificity of 74.0%.
Preoperative CA-125 and CA 19-9 levels combining pain score can be useful for the prediction of pelvic endometrinsis and may he included in the evaluation of unexulained infertile women.
确定血清癌胚抗原（CA）-125和CA 19-9联合疼痛评分在预测不孕女性盆腔子宫内膜异位症中的作用。
在因不孕接受腹腔镜检查前的卵泡期，采用免疫放射学方法检测血清CA-125和CA 19-9。所获值与子宫内膜异位症的发生及严重程度相关。应用受试者操作特征（ROC）曲线评估血清CA-125、CA 19-9和疼痛评分在术前准备中的作用。确定CA-125和CA 19-9的临界值。
该研究纳入了2010年7月至2011年9月期间接受腹腔镜检查的294例不孕女性。94例患者被诊断为子宫内膜异位症，200例未患该病。两组术前血清CA-125和CA 19-9水平有显著差异。血清CA-125和CA 19-9的ROC曲线分析设定临界值分别为18.25 IU/ml和13.15 IU/ml，敏感性分别为64.8%和84.8%，特异性分别为81.9%和51.6%，阳性预测值（PPV）分别为63.6%和46.1%，阴性预测值（NPV）分别为81.0%和87.4%。CA-125和CA 19-9的联合分析敏感性为72.4%，特异性为81.9%，PPV为62.3%，NPV为81.8%。血清CA-125、CA 19-9和疼痛评分的联合分析敏感性为71.0%，特异性为74.0%。
术前CA-125和CA 19-9水平联合疼痛评分有助于预测盆腔子宫内膜异位症，可纳入不明原因不孕女性的评估中。
