Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; Department of Public Health & Primary Care, Leuven University, Leuven, Belgium.
Toxicol Lett. 2018 Dec 1;298:42-52. doi: 10.1016/j.toxlet.2018.06.1213. Epub 2018 Jun 23.
Studies suggest that leukocyte telomere length is an index of systemic ageing. Here, we discuss telomere length as a marker of biological ageing in relation to residential landscape (greenness), residential air pollution and work-related exposures. Telomere lengths are memories of cumulative oxidative and inflammatory stress, and show to have inverse associations with the risk of non-communicable diseases. For this reason, telomeres are considered as markers of biological ageing. Studies at birth, in children, young adulthood, and elderly show that residential green space, lower traffic exposure and long-term lower exposure to particulate air pollution are associated with longer telomeres. Work-related exposures including exposure to toxic metals, polycyclic aromatic hydrocarbons and particulate matter are associated with shorter telomeres for a given age. In contrast to chronic exposures, evidence is present of the observation that recent exposure is associated with longer telomeres. Our overview shows that the magnitude of residential and work-related environmental factors on telomere length are often as important as many classical lifestyle factors.
研究表明，白细胞端粒长度是全身衰老的一个指标。在这里，我们讨论端粒长度作为生物衰老的标志物与居住景观（绿化）、居住空气污染和与工作相关的暴露之间的关系。端粒长度是累积氧化和炎症应激的记忆，并且与非传染性疾病的风险呈负相关。出于这个原因，端粒被认为是生物衰老的标志物。在出生、儿童、青年和老年进行的研究表明，居住绿地、交通暴露水平较低以及长期接触较低水平的颗粒物空气污染与端粒较长有关。与工作相关的暴露，包括接触有毒金属、多环芳烃和颗粒物，与给定年龄的较短端粒有关。与慢性暴露相反，有证据表明，最近的暴露与端粒较长有关。我们的综述表明，居住和与工作相关的环境因素对端粒长度的影响往往与许多经典的生活方式因素一样重要。
